RELATIONSHIP BETWEEN LIPID PROFILE RESULTS AND THE LEVEL OF MATRIX METALLOPROTEINASES IN BLOOD SERUM IN APPARENTLY HEALTHY WOMEN OF DIFFERENT AGES

AbstractSolving the problem of active longevity is extremely important both for humanity as a whole and for each individual. There is no unified theory of aging today. Gerontologists agree that aging is caused by many causes acting simultaneously or sequentially. At the same time, most modern theories are based on the study of individual processes occurring during the aging of the body. Aging alters lipid metabolism by regulating several important pathways involved in lipid transport. In addition, the retention of cholesterol-rich lipoprotein apeS in the artery wall causes several modifications and important biological consequences, including due to the influence of matrix metalloproteinases (MMPs), the expression of which increases with age. The aim of the study was to analyze the values of lipidogram, matrix metalloproteinases in women with age and to assess their relationship.  The study included 157 women, distributed by age (WHO). The subjects underwent the first stage of medical examination at the clinical bases of the Federal State Budgetary Educational Institution of the Russian Ministry of Health, where the levels of total cholesterol, high-density lipoproteins, low-density lipoproteins, triglycerides, apoliproteins A1, B and MMP values in blood serum were determined. Statistical processing of the obtained results was carried out using the IBM SPSS Statistics 26 program using nonparametric statistics methods. In conditionally healthy women, depending on age, the level of OH was high at the age of 45-59 years, in senile age it was significantly reduced. HDL was significantly reduced in the senile age group, while LDL was, on the contrary, increased. The level of APA in women under 45 years of age was reduced, and at the age of 60-74 years it was increased. The ApoV/ApoA1 index was lower at a young age compared to women over 45 years of age. In conditionally healthy women, MMP-1 values were higher in the middle-aged group. MMP-2 was higher in the middle-aged group, but its highest levels were recorded in the group of women over 75 years old. MMP-3 did not change depending on age. In women over 75 years of age, MMP-7 was lower than the values of the other groups. MMP-9 was higher in the group of women aged 45-59 years. According to the conducted correlation analysis, conditionally healthy women had direct medium-strength connections between the level of APA and MMP-2, which correlated with an increase in age.