Email this article FOOD SENSITIZATION IN PERENNIAL ALLERGIC RHINITIS AND BRONCHIAL ASTHMA
- Authors: Klimov A.V.1, Isaev P..2, Urazova O.I.1, Klimov V.V.1, Denisov A.A.1, Zagreshenko D.S.3, Kukharev Y.V.1, Khudyakova M.I.1, Shkatova A.N.1, Ovcharenko E.V.1, Selezneva O.A.1, Ryzhkova A.Y.1
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Affiliations:
- Siberian State Medical University, Tomsk, Russia
- Kanevskaya Central Hospital, village Kanevskaya, Russia
- Russian Continuous Postgraduate Education Academy, Novokuznetsk, Russia
- Section: Immunological readings in Chelyabinsk
- Submitted: 29.03.2025
- Accepted: 31.05.2025
- URL: https://rusimmun.ru/jour/article/view/17187
- DOI: https://doi.org/10.46235/1028-7221-17187-FSI
- ID: 17187
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Abstract
AbstractAtopic allergic diseases (atopies) are now becoming more common. Despite different locations of allergic inflammation, allergens that cause а sensitization can show a cross-reactivefeature, which raises the question of atopic comorbidity. A combination of allergic rhinitis with food allergies, as well as asthma with food allergies, is becoming more frequent, but still not well understood.
The aim of the work was to investigate food sensitization in perennial allergic rhinitis and asthma and to assess relationships between it and respiratory atopies due to preferential sensitization to the dust mite Dermatophagoides pteronissinus.
276 patients aged 18-60 years, both sexes, with perennial allergic rhinitis (n=168) and bronchial asthma (n =108), were examined, in whom blood concentrations of five specific antibodies of the IgE class to food allergens from the G8 group were determined, as well as antibodies to the most important allergen Der p 1 of dust mites Dermatophagoides pteronissinus, which are the leading source of sensitization in respiratory atopies. The data obtained were processed by descriptive statistics taking into account a distribution, calculation of non-parametric indicators, and correlation.
All patients were divided into three groups: without symptoms of food allergies and sensitization (46%), with the absence of clinical manifestations of food allergies, but detection of latent food sensitization (26.1%), and the presence of both symptoms and sensitization (27.9%). Thus, in more than half of the cases of allergic rhinitis and asthma, food sensitization was found. An expected correlation of average strength between antibodies to shrimp and dust mite allergens has been found. No association of IgE to Der p I with other food allergens was revealed.
However, there was a significantly higher frequency of clinical food allergies in asthma compared to allergic rhinitis, but a total accounting of subclinical and clinical sensitization, did not demonstrate a significant difference between each other. This may indicate a more reliable maintenance of allergen tolerance against food allergens or a lack of factors for breakdown of tolerance at the preclinical stage in allergic rhinitis compared to asthma.
About the authors
Andrew V. Klimov
Siberian State Medical University, Tomsk, Russia
Email: klimov.lor@mail.ru
ORCID iD: 0000-0002-2776-5834
PhD (Medicine), MD, Immunology&AllergyDept Associate Professor, and ENT Dept Assistant Professor, SibSMU, Tomsk, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaPaul Yu. Isaev
Kanevskaya Central Hospital, village Kanevskaya, Russia
Email: pavel_isaev80@mail.ru
ORCID iD: 0000-0001-9831-4814
Chief Medical Officer
Russian Federation, 108, Hospital street, Kanevskaya village, Krasnodar Territory, 353730.Ogla I. Urazova
Siberian State Medical University, Tomsk, Russia
Email: urazova.oi@ssmu.ru
ORCID iD: 0000-0002-9457-8879
ScD, PhD (Medicine), Corr. Member of RAS, Path. Physiol. Dept, Head, SibSMU, Tomsk, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaVladimir V. Klimov
Siberian State Medical University, Tomsk, Russia
Email: vlklimov54@gmail.com
ORCID iD: 0000-0001-6673-7556
ScD, PhD (Medicine), MD, Immunology&Allergy Dept Head, Siberian State Medical University (SibSMU), Immunology-in-Chief, Tomsk Region, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaAndrew A. Denisov
Siberian State Medical University, Tomsk, Russia
Email: denanalex@mail.ru
ORCID iD: 0000-0001-7592-5284
ScD, MD, Immunology&Allergy Dept, Professor, Siberian State Medical University (SibSMU), Tomsk, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaDenis S. Zagreshenko
Russian Continuous Postgraduate Education Academy, Novokuznetsk, Russia
Email: zagreshenko@rambler.ru
PhD (Medicine), MD, Clinical Laboratory Dept, Associate Professor, Russian Continuous Postgraduate Education Academy, Novokuznetsk branch, Novokuznetsk, Russia
Russian Federation, No. 5 Stroiteley Avenue, Novokuznetsk, Kemerovo region, 654005Yaroslav V. Kukharev
Siberian State Medical University, Tomsk, Russia
Email: kukharev78@mail.ru
ORCID iD: 0009-0007-0409-9334
PhD (Medicine), MD, Immunology&AllergyDept Assistant Professor, Siberian State Medical University (SibSMU), Tomsk, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaMaria I. Khudyakova
Siberian State Medical University, Tomsk, Russia
Email: khudiakovami@mail.ru
ORCID iD: 0000-0002-6320-5017
Research Center for Shared Equipment Center Use, SibSMU, Tomsk, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaAlina N. Shkatova
Siberian State Medical University, Tomsk, Russia
Email: alinashkatik@gmail.com
ORCID iD: 0009-0008-7915-290X
PhD (Medicine), MD, Allergy Unit Head, Student Policlinic, Tomsk, Russia
Russian Federation, 634041, Tomsk, Kievskaya street, 74Ekaterina V. Ovcharenko
Siberian State Medical University, Tomsk, Russia
Email: katovcha@gmail.com
ORCID iD: 0009-0000-4734-2786
Immunology&Allergy Dept, Researcher, SibSMU, Tomsk, Russia
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaOlga A. Selezneva
Siberian State Medical University, Tomsk, Russia
Email: helg.se@mail.ru
ORCID iD: 0009-0004-2335-3690
SibSMU, Pediatric Faculty, 5th year Student
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaAlina Yu. Ryzhkova
Siberian State Medical University, Tomsk, Russia
Author for correspondence.
Email: alya.ryzhkova.2003@mail.ru
ORCID iD: 0000-0002-7862-7992
Faculty of Medicine and Biology, 4th year Student
Russian Federation, Moskovsky trakt 2, Tomsk, 634050, RussiaReferences
- ImmunoCAP ISAC 112 for multiplex allergen testing. - https://www.nice.org.uk/guidance/dg24/resources/immunocap-isac-112-for-multiplex-allergen-testing-pdf-1053690256069
- Klimov V.V. Textbook of Allergen Tolerance. Cham: Springer, 2022, 325 pp. - DOI: https://doi.org/10.1007/978-3-031-04309-3.
- Larenas-Linnemann D., Luna-Pech J.A., Mёsges R. Debates in allergy medicine: allergy skin testing cannot be replaced by molecular diagnosis in the near future. WAO J., 2017, Vol.10 no. 32, pp. 1–7. - DOI: https://doi.org/10.1186/s40413-017-0164-1.
- Sarwar M. House dust mites: ecology, biology, prevalence, epidemiology and elimination. Ed. Pacheco G.A.B., Kamboh A.A. Parasitology and microbiology research,London: IntechOpen, 2020. - DOI: https://doi.org/10.5772/intechopen.91891.
- Sicherer S.H., Dampson H.A. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J. Allergy Clin.Immunol., 2018, Vol.141, no.1, pp. 41-58. - doi: 10.1016/j.jaci.2017.11.003.
- Testera-Montes A., Salas M., Palomares F., Ariza A., Torres M.J., Rondón C., Eguiluz-Gracia I. Local respiratory allergy: from rhinitis phenotype to disease spectrum. Front Immunol., 2021,Vol. 12, 691964. DOI: https://doi.org/10.3389/fmmu.2021.691964.
- Waserman S., Beegin P., Watson W. IgE-mediated food allergy. Allergy, Asthma and Clin. Immunol.,2018, Vol. 14, no. 2, pp. 71-81. - doi: 10.1186/s13223-018-0284-3.
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