THE ASSOCIATION OF SERUM ANGIOPOIETIN-LIKE PROTEINS TYPES 2, 3 AND 4 WITH CLINICAL MANIFESTATIONS OF OSTEOARTHRITIS



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Abstract

Abstract

Hyperfunction of angiopoietin-like proteins (ANGPTL) involved in the maintenance of chronic inflammation may lead to the progression of arthropathies of various genesis. Purpose of the study: to determine the relationship between the serum level of angiopoietin-like proteins types 2, 3 and 4 with clinical and laboratory characteristics of osteoarthritis (ОА) and comorbid conditions. 42 OA patients (women 78.6%, aged 59.2±8.7 years and disease duration 8.9±5.5 years) were examined More severe joint damage (when assessing the radiologic stage) was accompanied by an increase in the level of ANGPTL type 4 (p=0.014). The group of OA patients with synovitis had significantly higher rates of type 2 and type 4 ANGPTL than patients without synovitis (p=0.039 and p=0.021, respectively). The content of type 4 ANGPTL was also significantly higher in patients with high values of ESR and C-reactive protein (CRP) (p=0.018). The comorbid background of OA patients was mainly characterized by obesity (40.5%), arterial hypertension (AH) (38%) and the presence of metabolic syndrome (MetS) (31%). The levels of type 3 ANGPTL in patients with MS was higher than in OA patients without MetS (p=0.024). The levels of type 4 ANGPTL in obese patients was higher than in OA patients with normal body weight (p=0.027), and the index of type 3 ANGPTL in this group did not reach the level of statistical significance (p=0.052). The analysis of variance also showed a significant effect of obesity degree on the level of type 4 ANGPTL (p=0.034). The levels of ANGPTL types 2, 3 and 4 in the groups of OA patients with/without AH did not differ (p=0.11, p=0.055 and p=0.09, respectively), but when comparing patients with different degrees of AH, the difference in ANGPTL type 3 levels reached the level of statistical significance (p=0.049). In summary, ANGPTLs show different dependence on the comorbid background in patients with OA: type 2 ANGPTL is associated with inflammatory processes in the joints, type 3 ANGPTL with the presence of MetS and severity of AH, and type 4 ANGPTL with obesity, inflammation and severity of joint damage.

About the authors

Vladislav A. Aleksandrov

Volgograd State Medical University, Volgograd, Russian Federation;
Research Institute of Clinical and Experimental Rheumatology named after А.B. Zborovsky, Volgograd, Russian Federation

Email: alexandrow8349@gmail.com
ORCID iD: 0000-0002-4500-7172
SPIN-code: 8754-4898
Scopus Author ID: 57325978000
ResearcherId: С-6714-2018

Assistant Professor, Department of Hospital Therapy; Junior Research Associate

Russian Federation, 1, Pavshikh Bortsov Sq., Volgograd, 400131, Russian Federation; 76, Zemlyachki st., Volgograd, 400138, Russian Federation

Ludmila N. Shilova

Volgograd State Medical University, Volgograd, Russian Federation;
Research Institute of Clinical and Experimental Rheumatology named after А.B. Zborovsky, Volgograd, Russian Federation

Email: ludshilova@mail.ru
ORCID iD: 0000-0002-0438-8554
SPIN-code: 4950-2391

MD, PhD (Medicine), Head, Department of Hospital Therapy; Senior Research Associate

Russian Federation, 1, Pavshikh Bortsov Sq., Volgograd, 400131, Russian Federation; 76, Zemlyachki st., Volgograd, 400138, Russian Federation

Andrey V. Aleksandrov

Volgograd State Medical University, Volgograd, Russian Federation;
Research Institute of Clinical and Experimental Rheumatology named after А.B. Zborovsky, Volgograd, Russian Federation

Author for correspondence.
Email: imlab@mail.ru
ORCID iD: 0000-0002-0686-4067
SPIN-code: 4755-0940
Scopus Author ID: 25645530000
ResearcherId: С-6738-2018

MD, PhD (Medicine), Professor, Department of Clinical Laboratory Diagnostics; Head, Laboratory of Functional Research Methods, Ultrasound Diagnostics and Rehabilitation Therapy

Russian Federation, 1, Pavshikh Bortsov Sq., Volgograd, 400131, Russian Federation; 76, Zemlyachki st., Volgograd, 400138, Russian Federation

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