INFLUENCE OF THE COURSE OF ACUTE COVID-19 INFECTION ON THE COURSE OF POST-COVID SYNDROME



Cite item

Full Text

Abstract

Abstract

The COVID-19 coronavirus pandemic caused by the SARS-CoV-2 virus has resulted in global morbidity and high mortality worldwide. According to case histories, for a long time (from six months to 2-3 years) after acute COVID-19 infection, patients experience severe fatigue, increased fatigue, an increase in the incidence of acute respiratory viral infections per year, an increase in the recurrence of skin diseases, allergies, exacerbation of pulmonary pathology, urinary tract diseases, an increase in the recurrence of chronic infectious diseases such as herpesvirus and papillomavirus infections, and an aggravation of chronic cardiovascular and other somatic diseases of various organs and systems. Patients were examined at least six months after recovery from acute COVID-19. Such persistent post-infectious consequences are known as post-COVID syndrome. When assessing post-COVID syndrome, it is necessary to identify the main clinical syndromes of multiorgan pathology characteristic of post-COVID patients. Endocrine and cardiac manifestations of post-COVID syndrome can be a consequence of direct damage by the virus, immunological and inflammatory damage, as well as iatrogenic complications.

Objective of the study: to assess the impact of the severity of acute COVID-19 on the course of post-COVID syndrome.

Research objectives:

  1. To analyze the severity of clinical manifestations of the symptom complex of cardiovascular damage in post-COVID patients depending on the degree of lung damage in the acute period of COVID-19.
  2. To analyze the severity of clinical manifestations of endocrine system pathology, including newly diagnosed, in post-COVID patients depending on the degree of lung damage in the acute period of COVID-19. Since no statistically significant differences by gender and age were found, all patients were divided into groups by the degree of lung damage in the acute period of COVID-19 according to clinical guidelines for the diagnosis and treatment of a new coronavirus infection:

This study showed that the clinical picture of post-COVID syndrome is characterized by a pronounced diversity of the formation of multiple organ pathology, both newly diagnosed and manifested in an increase in the frequency of exacerbations of chronic diseases.

About the authors

Mariya Alexandrovna Dobrynina

Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections «Virome» Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing, Yekaterinburg

Email: mzurochka@mail.ru

PhD, MD, Researcher, laboratory ofimmunopathophysiology, Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg; Senior Researcher, Laboratory of Transmissible Viral Diseases, FBISFederal Scientific Research Institute of Viral Infections "VIROM" Federal Service for Supervision of Consumer Rights Protection and Human Consumption, Yekaterinburg;assistant professor of the Department of Therapy of the University of Innovation and Continuing Education of the State Research Center –Burnazyan Federal Medical Biophysical Center of  Federal Medical Biological Agency, Moscow, Russia

Russian Federation

Vladimir Alexandrovich Zurochka

Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections «Virome» Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing, Yekaterinburg

Email: v_zurochka@mail.ru

D.Sc. MD, senior researcher,laboratory ofimmunopathophysiology, Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences,Ekaterinburg; senior researcher, laboratory of immunobiotechnology, Russian-Chinese Center, South Ural State University (NRU),Chelyabinsk, Russia

Russian Federation

Alexandr Vladimirovich Zurochka

Federal Budgetary Institution of Science «Federal Scientific Research Institute of Viral Infections «Virome» Federal Service for Surveillance on Costumer Rights Protection and Human Wellbeing, Yekaterinburg

Author for correspondence.
Email: av_zurochka@mail.ru

honored worker of science of the Russian Federation, D.Sc. MD, professor, leading researcher, laboratory of immunopathophysiology, Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ekaterinburg; head of laboratory of immunobiotechnology of the Russian-Chinese Center of South Ural State University (NRU),Chelyabinsk, Russia

Russian Federation

References

  1. Канорский, С.Г. Постковидный синдром: распространенность и патогенез органных поражений, направления коррекции. Систематический обзор // Кубанский научный медицинский вестник. - 2021. - Т. 28 (6). - С.90-116. Kanorsky, S.G. Postcovoid syndrome: prevalence and pathogenesis of organ lesions, directions of correction. A systematic review // Kuban Scientific Medical Bulletin. 2021. Vol. 28 (6). pp.90-116.
  2. https://doi.org/10.25207/1608-6228-2021-28-6-90-116
  3. Лучевая диагностика коронавирусной болезни (COVID-19): организация, методология, интерпретация результатов: методические рекомендации № 72 / Препринт № ЦДТ - 2020 – I; ГБУЗ города Москвы «Научно-практический клинический центр диагностики и телемедицинских технологий Департамента здравоохранения города Москвы». Москва, 2020. 75 с. (Серия «Лучшие практики лучевой и инструментальной диагностики»).
  4. Radiation diagnostics of coronavirus disease (COVID-19): organization, methodology, interpretation of results: methodological recommendations No. 72 / Preprint No. CDT - 2020 – I; Moscow State Medical University "Scientific and Practical Clinical Center for Diagnostics and Telemedicine Technologies of the Moscow Department of Health". Moscow, 2020. 75 pages . (Series "Best practices of radiation and instrumental diagnostics"). doi: 10.17816/DD46791
  5. Международная классификация болезней 11 пересмотра: МКБ-11: глобальный стандарт для диагностической информации о здоровье: онлайн версия / Всемирная организация здоровья. 2022.
  6. International Classification of Diseases 11 revision: ICD-11: Global Standard for Diagnostic Information on Health: online version / World Health Organization. 2022. https://icd.who.int/ru.
  7. Международная статистическая классификация болезней и проблем, связанных со здоровьем, 10-го пересмотра, (МКБ-10): онлайн версия / Принята 43-ей Всемирной Ассамблеей Здравоохранения. 2019. Режим доступа:
  8. International Statistical Classification of Diseases and Related Health Problems, 10th Revision, (ICD-10): online version / Adopted by the 43rd World Health Assembly. 2019. Access mode: https://mkb-10.com /. https://mkb-10.com/..
  9. Подзолков В.И., Брагина А.Е. Тарзиманова А.И. Васильева Л.В. Батракова Е.В. Лобова Н.В. Быкова Е.Е. Хачуроева М.М. Постковидный синдром и тахикардия: теоретические основы и опыт лечения // Рациональная Фармакотерапия в Кардиологии. - 2021. - № 17 (2). Podzolkov V.I., Bragina A.E., Tarzimanova A.I., Vasilyeva L.V., Batrakova E.V., Lobova N.V., Bykova E.E., Khachuroeva M.M. Post-COVID syndrome and tachycardia: theoretical foundations and treatment experience // Rational Pharmacotherapy in Cardiology. - 2021. - No. 17 (2). - P. 256–262. doi: 10.20996/1819-6446-2021-04-08.
  10. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19): временные методические рекомендации / Минздрав России. Москва, 2023. 250 с. Версия 18 (26.10.2023).
  11. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19): temporary guidelines / Ministry of Health of Russia. Moscow, 2023. 250 p. Version 18 (10/26/2023). https://www.consultant.ru/document/
  12. cons_doc_LAW_347896/
  13. Costa L.B., Perez L.G., Palmeira V.A., Cordeiro T. M. , Ribeiro V. T. , Lanza K., Silva A. C. S. Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System. Front Cell Dev Biol, 2020 Sep 16; 8:559841.
  14. Costa L.B., Perez L.G., Palmeira V.A., Cordeiro T. M. , Ribeiro V. T. , Lanza K., Silva A. C. S. Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System. Front Cell Dev Biol, 2020 Sep 16; 8:559841.
  15. doi: 10.3389/fcell.2020.559841
  16. Gentile S., Strollo F. Mambro A., Ceriello A. COVID-19, ketoacidosis and new-onset diabetes:are there possible cause and effect relationshipsamong them? DiabetesObes. Metab, 2020, Vol. 22 (12), P. 2507–2508. Gentile S., Strollo F. Mambro A., Ceriello A. COVID-19, ketoacidosis and new-onset diabetes:are there possible cause and effect relationshipsamong them? DiabetesObes. Metab, 2020, Vol. 22 (12), P. 2507–2508. doi: 10.1111/dom.14170
  17. Huang C., Huang L. Wang Y., Li X., Ren L., Gu X. , Kang L., Guo L., Liu M., Zhou X., Luo J., Huang Z., Tu S., Zhao Y., Chen L., Xu D., Li Y., Li C. , Peng L. , Li Y., Xie W. , Cui D. , Shang L. , Fan G., Xu J. , Wang G. , Wang Y. , Zhong J. , Wang C. , Wang J. , Zhang D. , Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet, 2021, Vol. 397 (10270),P. 220–232. Huang C., Huang LWang Y., Li X., Ren L., Gu X. , Kang L., Guo L., Liu M., Zhou X., Luo J., Huang Z., Tu S., Zhao Y., Chen L., Xu D., Li Y., Li C. , Peng L. , Li Y., Xie W. , Cui D. , Shang L. , Fan G., Xu J. , Wang G. , Wang Y. , Zhong J. , Wang C. , Wang J. , Zhang D. , Cao B. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet, 2021, Vol. 397 (10270),P. 220–232. doi: 10.1016/S0140-6736(20)32656-8
  18. Lindner D. , Fitzek A. Bräuninger H., Aleshcheva G., Edler C., Meissner K., Scherschel K., Kirchhof P. , Escher F., Schultheiss H.P., Blankenberg S., Püschel K., Westermann D. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases JAMA Cardiol, 2020, Vol. 5 (11), P. 1281-1285. Lindner D. , Fitzek A. Bräuninger H., Aleshcheva G., Edler C., Meissner K., Scherschel K., Kirchhof P. , Escher F., Schultheiss H.P., Blankenberg S., Püschel K., Westermann D. Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases JAMA Cardiol, 2020, Vol. 5 (11), P. 1281-1285 doi: 10.1001/jamacardio.2020.3551
  19. Liu P.P, Blet A. Smyth D., Li H. The Science Underlying COVID-19: Implications for the Cardiovascular System.Circulation, 2020, Vol. 142 (1), P. 68-78. Liu P.P, Blet A. Smyth D., Li H. The Science Underlying COVID-19: Implications for the Cardiovascular System. Circulation, 2020, Vol. 142 (1), P. 68-78. doi: 10.1161/CIRCULATIONAHA.120.047549
  20. Müller J. A., Groß R. Conzelmann C., Krüger J., Merle U., Steinhart J., Weil T., Koepke L., Bozzo C. P., Read C., Fois G., Eiseler T., Gehrmann J., van Vuuren J., Wessbecher I. M., Frick M., Costa I. G., Breunig M., Grüner B., Peters L., Schuster M., Liebau S., Seufferlein T., Stenger S., Stenzinger A., MacDonald P. E., Kirchhoff F., Sparrer K. M. J., Walther P., Lickert H., Barth T. F. E., Wagner M., Münch J., Sandra Heller, Kleger A. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab, 2021, Vol. 3 (2), P. 149–165. Müller J. A., Groß R. Conzelmann C., Krüger J., Merle U., Steinhart J., Weil T., Koepke L., Bozzo C. P., Read C., Fois G., Eiseler T., Gehrmann J., van Vuuren J., Wessbecher I. M., Frick M., Costa I. G., Breunig M., Grüner B., Peters L., Schuster M., Liebau S., Seufferlein T., Stenger S., Stenzinger A., MacDonald P. E., Kirchhoff F., Sparrer K. M. J., Walther P., Lickert H., Barth T. F. E., Wagner M., Münch J., Sandra Heller, Kleger A. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab, 2021, Vol. 3 (2), P. 149–165. doi: 10.1038/s42255-021-00347-1
  21. Nehme M., Braillard O. Chappuis F., Courvoisier D. S. , Guessous I.; CoviCare Study Team. Prevalence of Symptoms More Than Seven Months After Diagnosis of Symptomatic COVID-19 in an Outpatient Setting. Ann. Intern. Med, 2021,Vol. 174(9), P. 1252-1260.
  22. Nehme M., Braillard O. Chappuis F., Courvoisier D. S. , Guessous I.; CoviCare Study Team. Prevalence of Symptoms More Than Seven Months After Diagnosis of Symptomatic COVID-19 in an Outpatient Setting. Ann. Intern. Med, 2021,Vol. 174(9), P. 1252-1260. doi: 10.7326/M21-0878
  23. Pierce J.D., Shen Q. Cintron S.A., Hiebert J.B. Post-COVID-19 Syndrome. Nurs Res, 2022, Vol. 71 (2), P. 164-174. Pierce J.D., Shen Q. Cintron S.A., Hiebert J.B. Post-COVID-19 Syndrome. Nurs Res, 2022, Vol. 71 (2), P. 164-174. doi: 10.1097/NNR.0000000000000565.
  24. Rubino F., Amiel S. Zimmet P., Alberti G., Bornstein S., Eckel R., Mingrone G., Boehm B., Cooper M. E ., Chai Z. , Del Prato S., Linong Ji , Hopkins D, Herman W.H. , Khunti K., Mbanya J.C., Renard E. N. New-onset diabetesin COVID-19. Engl. J. Med, 2020, Vol. 383(8), P. 789–790.
  25. Rubino F., Amiel S. Zimmet P., Alberti G., Bornstein S., Eckel R., Mingrone G., Boehm B., Cooper M. E ., Chai Z. , Del Prato S., Linong Ji , Hopkins D, Herman W.H. , Khunti K., Mbanya J.C., Renard E. N. New-onset diabetesin COVID-19. Engl. J. Med, 2020, Vol. 383(8), P. 789–790.
  26. doi: 10.1056/NEJMc2018688
  27. Ruggeri R.M., Campenni A. Siracusa M., Frazzetto G., Gullo D. Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic.Hormones (Athens), 2021, Vol. 20 (1), P. 219–221. Ruggeri R.M., Campenni A. Siracusa M., Frazzetto G., Gullo D. Subacute thyroiditis in a patient infected with SARS-COV-2: an endocrine complication linked to the COVID-19 pandemic.Hormones (Athens), 2021, Vol. 20 (1), P. 219–221. doi: 10.1007/s42000-020-00230-w
  28. Siripanthong B., Nazarian S. Muser D., Deo R., Santangeli P., Khanji M. Y., Cooper Jr L. T., C Anwar A Chahal. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart Rhythm, 2020, Vol. 17 (9), P. 1463-1471. Siripanthong B., Nazarian S. Muser D., Deo R., Santangeli P., Khanji M. Y., Cooper Jr L. T., C Anwar A Chahal. Recognizing COVID-19-related myocarditis: The possible pathophysiology and proposed guideline for diagnosis and management. Heart Rhythm, 2020, Vol. 17 (9), P. 1463-1471. doi: 10.1016/j.hrthm.2020.05.001
  29. Suwanwongse K., Shabarek N. Newly diagnosed diabetes mellitus, DKA, and COVID-19: Causality or coincidence? A report of three cases. J. Med. Virol, 2021, Vol. 93 (2), P. 1150–1153. Suwanwongse K., Shabarek N. Newly diagnosed diabetes mellitus, DKA, and COVID-19: Causality or coincidence? A report of three cases. J. Med. Virol, 2021, Vol. 93 (2), P. 1150–1153. 1. doi: 10.1002/jmv.26339
  30. Tang X., Uhl S. Zhang T., Xue D., Li B., Vandana J. J., Acklin J. A., Bonnycastle L. L., Narisu N., Erdos M. R., Bram Y., Chandar V., Angie Chi Nok Chong , Lacko L. A., Min Z., Lim J. K., Borczuk A. C., Xiang J., Naji A., Collins F. S., Evans T., Liu C., tenOever B. R., Schwartz R. E., Chen S. SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab, 2021, Vol. 33(8), P. 1577-1591. e7. Tang X., Uhl S. Zhang T., Xue D., Li B., Vandana J. J., Acklin J. A., Bonnycastle L. L., Narisu N., Erdos M. R., Bram Y., Chandar V., Angie Chi Nok Chong , Lacko L. A., Min Z., Lim J. K., Borczuk A. C., Xiang J., Naji A., Collins F. S., Evans T., Liu C., tenOever B. R., Schwartz R. E., Chen S. SARS-CoV-2 infection induces beta cell transdifferentiation.Cell Metab, 2021, Vol. 33(8), P. 1577-1591. e7. doi: 10.1016/j.cmet.2021.05.015.
  31. Wu Q., Zhou L. Sun X., Yan Z., Hu C., Wu J., Xu L. , Li X. , Liu H., Yin P., Li K. , Zhao J. , Li Y. , Wang X., Li Y. , Zhang Q. , Xu G., Chen H Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.Sci Rep, 2017, Vol. 7 (1), P. 9110. Wu Q., Zhou L.. Sun X., Yan Z., Hu C., Wu J., Xu L. , Li X. , Liu H., Yin P., Li K. , Zhao J. , Li Y. , Wang X., Li Y. , Zhang Q. , Xu G., ChenH Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection Sci Rep, 2017, Vol. 7 (1), P. 9110. doi: 10.1038/s41598-017-09536-z

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) Dobrynina M.A., Zurochka V.A., Zurochka A.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies