Email this article DIFFERENTIATED APPROACHES TO TERGETED INTERFERON AND IMMUNOTHERAPY OF ATYPICAL CHRONIC ACTIVE INFECTION CAUSED BY EPSTEIN-BARR VIRUS
- Authors: Nesterova I.V.1,2, Khalturina E.O.3,2, Stepanov O.G.4, Malinovskaya V.V.5
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Affiliations:
- The Peoples’ Friendship University of Russia
- The MEDSI Academy
- I. M. Sechenov First Moscow State Medical University, Moscow (Sechenov University)
- The state Institution of science “Central research Institute for Epidemiology” of Rospotrebnadzor RF
- Federal scientific center of epidemiology and Microbiology. N. F. Gamalei
- Issue: Vol 22, No 2-1 (2019)
- Pages: 438-441
- Section: ORIGINAL ARTICLES
- Submitted: 11.05.2020
- Accepted: 11.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/176
- DOI: https://doi.org/10.31857/S102872210006923-0
- ID: 176
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Abstract
The problem of effective therapy of atypical chronic active EBV infection associated with chronic fatigue syndrome (AHA-VEBI) is extremely relevant at the present time. The study revealed the features of the defective functioning of the system of antiviral immune protection, as well as violations in the interferon system in patients suff ering from AHA-WEBI. The main clinical syndromes associated with AHA-WEBI were determined, immunopathogenetic features were clarified, the disease arose and progressed against the background, algorithms of complex diagnostics, including immunodiagnosis, and therapy were developed. The concept of diff erentiated, complex, etio- and immunopathogenetic therapy was developed and tested.
About the authors
I. V. Nesterova
The Peoples’ Friendship University of Russia;The MEDSI Academy
Author for correspondence.
Email: fake@neicon.ru
Doctor of Medical Sciences (MD), Professor, Professor of the Department of Allergology and Immunology;
Head of the Department of clinical immunology and allergology,
Moscow
Russian FederationE. O. Khalturina
I. M. Sechenov First Moscow State Medical University, Moscow (Sechenov University);The MEDSI Academy
Email: fake@neicon.ru
Ph.D. (Medical Science), Associate Professor of the Department of Microbiology, Virology and and Immunology;
the doctor allergologist – immunologist, the leading specialist in Clinical and diagnostic center “MEDSI on Belorusskaya»,
Moscow
Russian FederationO. G. Stepanov
The state Institution of science “Central research Institute for Epidemiology” of Rospotrebnadzor RF
Email: fake@neicon.ru
Researcher, Central Research Laboratory of immunology and biotechnology,
Moscow
Russian FederationV. V. Malinovskaya
Federal scientific center of epidemiology and Microbiology. N. F. Gamalei
Email: fake@neicon.ru
head of the laboratory of ontogenesis of interferons,
Moscow
Russian FederationReferences
- Nesterova I.V., Nguen T. D.L., Khalturina E. O., Malinovskaya V. V. Phenotypical Transformations of IFNα/ βR1+IFNγR+TLR4+ Subpopulation of Neutrophilic Granulocytes in Chronic Herpes-viral Infections and their Experimental Modulation by Recombinant IFNα2b Asthma, COPD, Immunophysiology & Immunorehabilitology: Innovative Technologies Volume 10–2018 P. 277–285.
- Levin L., Munger K., O’Reilly E., Falk K., Ascherio A. // Primary infection with Epstein-Barr virus and risk of multiple sclerosis. Ann Neurol. 2010. 67: 824–830.
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