IMMUNOENDOCRINE AND PSYCHOLOGICAL CRITERIA OF PREDICTING THE EFFICIENCY OF THERAPY IN PATIENTS SUFFERING FROM ADJUSTMENT DISORDER WITH ANXIETY-DEPRESSIVE SYMPTOMS

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Abstract

According to the results of psychological and immunoendocrine examination of patients with adjustment disorder prior to treatment, it is possible to predict the efficiency of standard psychopharmacotherapy. A high level of state, trait anxiety and prolactin concentration, low values of the number of natural killer cells and the phagocytic index of neutrophils can be considered as predictors for an ineffective treatment of adjustment disorders.

About the authors

V. B. Nikitina

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Author for correspondence.
Email: valentina08@sibmail.com

MD, Head of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology,

Tomsk

Russian Federation

O. A. Lobacheva

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: fake@neicon.ru

MD, lead researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology,

Tomsk

Russian Federation

M. F. Belokrylova

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: fake@neicon.ru

MD, lead researcher of the Borderline States Department, 

Tomsk

Russian Federation

V. A. Rudnitsky

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: fake@neicon.ru

MD, lead researcher of the Borderline States Department,

Tomsk

Russian Federation

E. M. Epanchintseva

Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Email: fake@neicon.ru

PhD, Head of the 1st Clinical Psychiatric Unit,

Tomsk

Russian Federation

References

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  2. Никитина В. Б., Лобачева О. А., Ветлугина Т. П., Аксенов М. М., Лебедева В. Ф. Нейроиммуноэндокринные нарушения при психических расстройствах и болезнях зависимости. Сибирский вестник психиатрии и наркологии. 2018, 2(99), 45–55.
  3. Labad J., Stojanovic-Pérez A., Montalvo I., Solé M., Cabezas Á., Ortega L., Moreno I., Vilella E., Martorell L., Reynolds R. M., Gutiérrez-Zotes A. Stress biomarkers as predictors of transition to psychosis in at-risk mental states: roles for cortisol, prolactin and albumin. J. Psychiatr Res. 2015, 60, 163–169.
  4. Абакушина Е. В., Кузьмина Е. Г., Коваленко Е. И. Основные свойства и функции NK-клеток человека. Иммунология. 2012., 4, 220–225.
  5. Адо А. Д., Маянский А. Н. Современное состояние учения о фагоцитозе. Иммунология. 1983, 1, 20– 26.

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Copyright (c) 2019 Nikitina V.B., Lobacheva O.A., Belokrylova M.F., Rudnitsky V.A., Epanchintseva E.M.

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