Email this article INFLUENCE OF FOCAL INFECTION ON THE CYTOKINE PROFILE IN PATIENTS WITH CHRONIC DERMATOSIS
- Authors: Patrushev A.V.1, Sukharev A.V.1, Nikitin V.Y.1, Ivanov A.M.1, Sukhina I.A.1, Gumilevskaya O.P.1
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Affiliations:
- Military Medical Academy
- Issue: Vol 22, No 2-1 (2019)
- Pages: 455-458
- Section: ORIGINAL ARTICLES
- Submitted: 12.05.2020
- Accepted: 12.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/181
- DOI: https://doi.org/10.31857/S102872210006928-5
- ID: 181
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Abstract
The aim of the study was to assess the impact of focal infection foci (FI) on the cytokine profile of patients with psoriasis, lichen planus (LP) and atopic dermatitis (AD). The patients were divided into two groups: those with FI (psoriasis – 19 people, AD – 13 people, LP – 14 people) and those without FI (psoriasis – 17 people, AD – 11 people, LP – 13 people). The control group was also examined – 15 healthy individuals. Immunoenzyme method was used to determine the following cytokines in the blood serum of patients: IL-1β, IL-2, IL-4, IL-6, IL8, IL-10, TNF-α, INF-α, INF-γ. It was shown that on the background of the presence of FI, the content of IL-8 in blood serum significantly increased (in 89,5% of cases in patients with psoriasis, in 76,6% in LP patients and in 100% in patients with AD).
About the authors
A. V. Patrushev
Military Medical Academy
Author for correspondence.
Email: alexpat2@yandex.ru
PhD, Assistant, Department of skin and venereal diseases,
St. Petersburg
Russian FederationA. V. Sukharev
Military Medical Academy
Email: fake@neicon.ru
MD, Professor, Department of skin and venereal diseases,
St. Petersburg
Russian FederationV. Yu. Nikitin
Military Medical Academy
Email: fake@neicon.ru
MD, Head of the immunological laboratory of the center for clinical laboratory diagnostics,
St. Petersburg
Russian FederationA. M. Ivanov
Military Medical Academy
Email: fake@neicon.ru
MD, Professor, Head of Department of clinical biochemistry and laboratory diagnostics,
St. Petersburg
Russian FederationI. A. Sukhina
Military Medical Academy
Email: fake@neicon.ru
PhD, Department of clinical biochemistry and laboratory diagnostics,
St. Petersburg
Russian FederationO. P. Gumilevskaya
Military Medical Academy
Email: fake@neicon.ru
MD, Head of the center for clinical laboratory diagnostics,
St. Petersburg
Russian FederationReferences
- Фисун А. Я., Черкашин Д. В., Макиев Р. Г., Кириченко П. Ю. «Очаговая инфекция» – фактор риска или патогенетическая основа возникновения заболеваний системы кровообращения. Вестник Российской военно-медицинской академии. 2015, 3(51), 7–16.
- Патрушев А. В., Самцов А. В., Иванов А. М., Сухарев А. В., Асфендиаров Д. Д. Распространенность очагов хронической инфекции у больных Т-клеточноопосредованными дерматозами. Вестник дерматологии и венерологии. 2018, 94(3), 30–38.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).