STRUCTURAL AND FUNCTIONAL CHARACTERISTIC OF CELLULAR ARM OF THE IMMUNE RESPONSE IN CHILDREN WITH BRONCHIAL ASTHMA

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Abstract

We have studied the structural and functional parameters of cellular component of immune system in 120 children with verified diagnosis of bronchial asthma (BA) and 30 healthy children of the same age. To analyze cellular parameters, we used flow cytofluorometer COULTER EPICS XL by Beckman Coulter Inc. with statistical processing by Statistica 10 program with critical significance level p<0.05. As compared to the healthy children’s parameters, the children with BA showed higher level of Th17, decreased absolute number of lymphocytes, B- and T-lymphocytes, with the increase in the share of Tlymphocytes with the early and late activation markers. The studies performed identifi ed in children with BA the changes in the pattern of lymphocyte subpopulations and functional activity of T-lymphocytes which determine the immune response imbalance, activation of antigen recognition regulation, triggering and realization of immune response, lymphocyte proliferation and differentiation.

About the authors

E. V. Prosekova

Federal State Budgetary Educational Institution of Higher Education “Pacific State Medical University” of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: pros.ev@mail.ru

Doctor of Medical Sciences, Full Professor, Head of Department of Clinical Laboratory Diagnostics and General and Clinical Immunology,

Vladivostok

Russian Federation

T. S. Sitdikova

Regional State Budgetary Healthcare Institution “Vladivostok Clinical and Diagnostic Centre”

Email: fake@neicon.ru

Allergist and Clinical Immunologist, Head of Department,

Vladivostok

Russian Federation

A. I. Turyanskya

Federal State Budgetary Educational Institution of Higher Education “Pacific State Medical University” of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

Assistant of Department of Clinical Laboratory Diagnostics and General and Clinical Immunology,

Vladivostok

Russian Federation

References

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  2. Курбачева О. М., Павлова К. С. Фенотипы и эндотипы бронхиальной астмы: от патогенеза и клинической картины к выбору терапии. Российский аллергологический журнал. 2013, 1, 15–24.
  3. Massimo Triggiani, Marek Jutel, Edward F. Knol. The Underlying Mechanisms of Asthma. EAACI Global Atlas of Asthma. Zurich: European Academy of Allergy and Clinical Immunology. 2013. Р. 31–34.
  4. Willem van de Veen., Mübeccel Akdis. Mechanisms of immuneregulation in allergy. EAACI Global Atlas of allergy. Zurich: European Academy of Allergy and Clinical Immunology. 2014, 90–91.
  5. Литвинова Л. С., Гуцол А. А., Сохоневич Н. А., Кофанова К. А., Хазиахматова О. Г., Шуплецова В. В., Кайгородова Е. В., Гончаров А. Г. Основные поверхностные маркеры функциональной активности Т-лимфоцитов. Медицинская иммунология. 2014, 16 (1):7–26.

Copyright (c) 2019 Prosekova E.V., Sitdikova T.S., Turyanskya A.I.

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