Email this article APPLICATION OF GENOTYPING CYP3A5 POLYMORPHISM FOR CORRECTING DOSE OF TACROLIMUS IN KIDNEY TRANSPLANTATION
- Authors: Ruzibakiyeva M.R.1, Aripova T.U.1, Hadzhibaev F.A.2, Sharipov V.K.2, Azizova Z.S.1
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Affiliations:
- Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
- Republican Specialized Scientific Center for Emergency Medical Aid of the Ministry of Health of the Republic of Uzbekistan
- Issue: Vol 22, No 2-1 (2019)
- Pages: 499-502
- Section: ORIGINAL ARTICLES
- Submitted: 13.05.2020
- Accepted: 13.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/196
- DOI: https://doi.org/10.31857/S102872210006944-3
- ID: 196
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Abstract
Currently, according to standard immunosuppression protocols after organ transplantation, tacrolimus is used as a part of immunosuppressive therapy. Along with obtaining the desired immunosuppressive effect, the problem of the development of unwanted adverse reactions to this drug is highly relevant. Pharmacogenetic testing of genotyping of the polymorphism of CYP3A5 G6986A, allows a personalized approach to the selection of the dosing regimen of tacrolimus, may increase the number of patients in whom the concentration of tacrolimus will be within the therapeutic range and will not exceed the acceptable toxicity level.
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About the authors
M. R. Ruzibakiyeva
Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
Author for correspondence.
Email: malika-ruz@hotmail.com
PhD, Senior Researcher,
Tashkent
UzbekistanT. U. Aripova
Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
Email: fake@neicon.ru
MD, Academician of the Academy of Sciences of Uzbekistan, Director of the Institute,
Tashkent
UzbekistanF. A. Hadzhibaev
Republican Specialized Scientific Center for Emergency Medical Aid of the Ministry of Health of the Republic of Uzbekistan
Email: fake@neicon.ru
D.M.S., Head of Surgery Department,
Tashkent
UzbekistanV. Kh. Sharipov
Republican Specialized Scientific Center for Emergency Medical Aid of the Ministry of Health of the Republic of Uzbekistan
Email: fake@neicon.ru
MD, Head of the Department of Anaesthesiology and Reanematology,
Tashkent
UzbekistanZ. Sh. Azizova
Institute of Human Immunology and Genomics, Academy of Sciences of Uzbekistan
Email: fake@neicon.ru
junior researcher,
Tashkent
UzbekistanReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).