Email this article TUMOR STEM CELLS AND THEIR MICRO-ENVIRONMENT: THE ROLE IN THE DEVELOPMENT OF THE TUMOR
- Authors: Sagakyants A.B.1, Novikova I.A.1, Ulyanova E.P.1, Zolotareva E.I.1, Shaposhnikov A.V.1, Dzhenkova E.A.1
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Affiliations:
- Rostov Research Institute of Oncology
- Issue: Vol 22, No 2-1 (2019)
- Pages: 512-514
- Section: ORIGINAL ARTICLES
- Submitted: 14.05.2020
- Accepted: 14.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/201
- DOI: https://doi.org/10.31857/S102872210006948-7
- ID: 201
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Abstract
Cancer stem cells (CSC) are a special functional group of cells in a heterogeneous tumor population, causing both the maintenance and growth of a tumor, metastasis processes, and resistance to various chemotherapeutic drugs. The questions of a comprehensive study of the dynamics of the structural and functional organization of CSC niches, the role of its individual components in maintaining these cells and prognosis of their future behavior remain topical. This paper is devoted to the consideration of the biological properties of cancer stem cells, their interaction with some components of their microenvironment and the role of this interaction in maintaining the properties of CSC.
About the authors
A. B. Sagakyants
Rostov Research Institute of Oncology
Author for correspondence.
Email: asagak@rambler.ru
Ph.D., Associate Professor, Head of the Laboratory of Immunophenotyping of tumors,
Rostov-on-Don
Russian FederationI. A. Novikova
Rostov Research Institute of Oncology
Email: fake@neicon.ru
PhD, Deputy General Director for Science,
Rostov-on-Don
Russian FederationE. P. Ulyanova
Rostov Research Institute of Oncology
Email: fake@neicon.ru
research fellow, Laboratory of Immunophenotyping of tumors,
Rostov-on-Don
Russian FederationE. I. Zolotareva
Rostov Research Institute of Oncology
Email: fake@neicon.ru
research fellow, Laboratory of Immunophenotyping of tumors,
Rostov-on-Don
Russian FederationA. V. Shaposhnikov
Rostov Research Institute of Oncology
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor, Chief Researcher of the Thoraco-Abdominal Department,
Rostov-on-Don
Russian FederationE. A. Dzhenkova
Rostov Research Institute of Oncology
Email: fake@neicon.ru
Doctor of Biological Sciences, Associate Professor, Scientific secretary,
Rostov-on-Don
Russian FederationReferences
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