Email this article FEATURES OF THE PRODUCTION OF INTERLEUKIN-5 IN ATHEROSCLEROSIS OF THE BRACHIOCEPHALIC ARTERIES
- Authors: Saranchina Y.V.1, Kilinа O.Y.1, Dutova S.V.1, Pol’shcha N.G.1, Kulakova T.S.1, Chanarin N.V.1, Shandakov P.I.2
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Affiliations:
- Khakass state University named after N. F. Katanov
- Republican clinical hospital named after G. YA. Remishevskaya
- Issue: Vol 22, No 2-1 (2019)
- Pages: 521-523
- Section: ORIGINAL ARTICLES
- Submitted: 14.05.2020
- Accepted: 14.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/204
- DOI: https://doi.org/10.31857/S102872210006951-1
- ID: 204
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Abstract
The article presents the results of interleukin-5 (IL-5) determination in patients with atherosclerosis (AS) of brachiocephalic arteries. It was found that the content of IL-5 in the serum of AS patients was signifi cantly lower than in the control group. Spontaneous and PHA-induced IL-5 production determined in blood leukocyte culture was signifi cantly lower in the group with as compared to the control group. Reduction of reserve capacity for IL-5 production by blood leukocytes was noted in both groups. Comparative analysis of IL-5 content in blood serum of AS patients and in atherosclerotic plaque homogenate did not reveal statistically signifi cant diff erences.
About the authors
Yu. V. Saranchina
Khakass state University named after N. F. Katanov
Author for correspondence.
Email: july.saran4ina.2010@yandex.ru
PhD, associate Professor of the Department of fundamental medicine and hygiene,
Abakan
Russian FederationO. Yu. Kilinа
Khakass state University named after N. F. Katanov
Email: fake@neicon.ru
doctor of medical Sciences, Director of Medical-psychological-social Institute, Professor of the Department of internal diseases,
Abakan
Russian FederationS. V. Dutova
Khakass state University named after N. F. Katanov
Email: fake@neicon.ru
doctor of science, associate Professor, acting head of the Department of fundamental medicine and hygiene of Medical, psychological and social Institute,
Abakan
Russian FederationN. G. Pol’shcha
Khakass state University named after N. F. Katanov
Email: fake@neicon.ru
PhD, associate Professor in the Department of internal diseases,
Abakan
Russian FederationT. S. Kulakova
Khakass state University named after N. F. Katanov
Email: fake@neicon.ru
post-graduate student of the Department of General professional disciplines,
Abakan
Russian FederationN. V. Chanarin
Khakass state University named after N. F. Katanov
Email: fake@neicon.ru
PhD, associate Professor of the Department of General professional disciplines,
Abakan
Russian FederationP. I. Shandakov
Republican clinical hospital named after G. YA. Remishevskaya
Email: fake@neicon.ru
PhD, head of the Department of vascular surgery,
Abakan
Russian FederationReferences
- Silveira A., McLeod O., Strawbridge R. J., Gertow K., Sennblad B., Baldassarre D., Veglia F., Deleskog A., Persson J., Leander K., Gigante B., Kauhanen J., Rauramaa R., Smit A. J., Mannarino E., Giral P., Gustafsson S., Söderberg S., Öhrvik J., Humphries S. E., Tremoli E., de Faire U., Hamsten A. Plasma IL-5 concentration and subclinical carotid atherosclerosis. Atherosclerosis. 2015, 239(1), 125–30.
- Ishigami T., Abe K., Aoki I., Minegishi S., Ryo A., Matsunaga S., Matsuoka K., Takeda H., Sawasaki T., Umemura S., Endo Y. Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels. FASEB J. 2013, 27(9), 3437–45.
- Zhao W., Lei T., Li H., Sun D., Mo X., Wang Z., Zhang K., Ou H. Macrophage-specific overexpression of interleukin-5 attenuates atherosclerosis in LDL receptor-deficient mice. Gene Ther. 2015, 22(8), 645–52.
- McLeod O., Silveira A., Valdes-Marquez E., Björkbacka H., Almgren P., Gertow K., Gådin J. R., Bäcklund A., Sennblad B., Baldassarre D., Veglia F., Humphries S. E., Tremoli E., de Faire U., Nilsson J., Melander O., Hopewell J.C., Clarke R., Björck H. M., Hamsten A., Öhrvik J., Strawbridge R. J. Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease. Cytokine. 2016, 81, 1–9.
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