Email this article DIFFERENTIATION OF CD8+ LYMPHOCYTES AND THEIR CYTOLYTIC ACTIVITY IN WOMEN WITH THREATED PRETERM LABOR
- Authors: Sotnikova N.Y.1, Borzova N.Y.1, Radjabova N.R.1
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Affiliations:
- Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 563-565
- Section: ORIGINAL ARTICLES
- Submitted: 18.05.2020
- Accepted: 18.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/217
- DOI: https://doi.org/10.31857/S102872210006975-7
- ID: 217
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Abstract
The aim of this work was to determine the features of diff erentiation of effector cytotoxic T lymphocytes (CTL) in women with threated preterm labor. Under observation were 100 pregnant women of 24–34 weeks of pregnant: the main group consisted of 44 women with threated preterm labor, control group – of 56 women with uncomplicated course of gestation. The relative content of CD8 cells, CD8 naïve cells (Tn), CD8 memory cells: Central (Tcm), preterminal-differentiated (Tem) and terminal differentiated (Temra) was studied in perephiral bloded. The content of CD8 cells producing Perforin was assessed in the total population of lymphocytes (CD8 Perf), as well as in populations of CD8 Tcm, Tem, Temra cells. The results of the study showed that women with threated preterm labor was characterized by a significant increase in the relative content of CD8 and CD8 Perf+ lymphocytes. The content of naive cells was significantly increased in the population of CD8 CTLs in women with exercise. In addition, there was a significant increase compared to that in control group the content of Perforin-producing cells in the fractions of Tcm, Tem and Temra cell memory.
About the authors
N. Yu. Sotnikova
Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
Author for correspondence.
Email: fake@neicon.ru
MD, head of the laboratory of clinical immunology,
Ivanovo
Russian FederationN. Yu. Borzova
Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
MD, assistant professor, senior researcher of Department of obstetrics and gynecology,
Ivanovo
Russian FederationN. R. Radjabova
Federal State Institution “Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov” the Ministry of Health of the Russian Federation
Email: nailaradjabova@yandex.ru
junior researcher of the Department of Obstetrics and Gynecology Neonatology,
Ivanovo
Russian FederationReferences
- Romero R., Chaemsaithong P., Chaiyasit N., Docheva N., Dong Z., Kim C. J., Kim Y. M., Kim J. S., Qureshi F., Jacques S. M., Yoon B. H., Chaiworapongsa T., Yeo L., Hassan S. S., Erez O., Korzeniewski S. J. CXCL10 and IL-6: Markers of two different forms of intra-amniotic inflammation in preterm labor. Am. J Reprod. Immunol.2017;78(1):1–62.
- Lee J., Romero R., Xu Y., Kim J. S., Topping V., Yoo W., Chaiworapongsa T., Mittal P., Hassan S. S., Kim C. J. A signature of maternal anti-fetal rejection in spontaneous preterm birth: chronic chorioamnionitis, antihuman leukocyte antigen antibodies Histopathology 2011; 59(5): 928–38.
- Кудряшова А. В., Кадырова Л. В. Дифференцировка СD+ клеток памяти при беременности. Российский иммунологический журнал 2014, 8(17), 1, 79–82.
- Кадырова Л. В., Борзова Н. Ю., Иваненкова Н. И. Особенности дифференцировки Т-лимфоцитов при невынашивании в ранние сроки гестации./ Российский иммунологический журнал 2013, 7(16), 2–3, 275.
- Barry M., Bleackley R. C. Cytotoxic T-lymphocytes: all roads lead to death. Nat. Rev.Immunol., 2002, Vol. 2, no. 6, pp. 401–409.
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