Email this article CONTRIBUTION OF PERIPHERAL BLOOD MONOCYTES IN THE FUNCTIONAL STRATEGY OF THE IMMUNE SYSTEM IN BREAST CANCER
- Authors: Stakheyeva M.N.1,2, Patysheva M.R.1, Tarabanovskaya N.A.1, Kzhyshkowska J.G.2, Cherdyntseva N.V.1,2
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Affiliations:
- Cancer Research Institute, Tomsk National Research Medical Center of the RAS
- Tomsk State University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 569-571
- Section: ORIGINAL ARTICLES
- Submitted: 18.05.2020
- Accepted: 18.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/219
- DOI: https://doi.org/10.31857/S102872210006977-9
- ID: 219
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Abstract
The phenotypic and expression characteristics of peripheral blood monocytes were evaluated in relationship to the antitumor and tumor-stimulating state of the immune system. It has been shown that the favorable state of the immune system associated with prolonged clinical remission is characterized by a higher level of functional activation of peripheral blood monocytes, which is manifested in a more pronounced expression of the TNFα and YLK-39 genes and a higher proportion of TLR2+ monocytes compared with the corresponding indicators in patients with unfavorable status.
Keywords
About the authors
M. N. Stakheyeva
Cancer Research Institute, Tomsk National Research Medical Center of the RAS;Tomsk State University
Author for correspondence.
Email: stakheyevam@oncology.tomsk.ru
MD, PhD, the leading of Cancer Research Institute;
the senior researcher of the laboratory of translational cellular and molecular biomedicine,
Tomsk
Russian FederationM. R. Patysheva
Cancer Research Institute, Tomsk National Research Medical Center of the RAS
Email: fake@neicon.ru
junior researcher,
Tomsk
Russian FederationN. A. Tarabanovskaya
Cancer Research Institute, Tomsk National Research Medical Center of the RAS
Email: fake@neicon.ru
PhD, researcher,
Tomsk
Russian FederationJ. G. Kzhyshkowska
Tomsk State University
Email: fake@neicon.ru
PhD, Professor, the Head of the Laboratory of translational cellular and molecular biomedicine,
Tomsk
Russian FederationN. V. Cherdyntseva
Cancer Research Institute, Tomsk National Research Medical Center of the RAS;Tomsk State University
Email: fake@neicon.ru
PhD, Professor, Corresponding member of Russian Academy of Sciences, the Head of the Laboratory of Molecular oncology and immunology;
The leading researcher of Laboratory of translational cellular and molecular biomedicine,
Tomsk
Russian FederationReferences
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- Zitvogel L., Galluzzi L., Smyth M. J., Kroemer G. Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance. Immunity. 2013, 39, 74–88.
- Stakheyeva M., Eidenzon D., Cherdyntseva N., Slonimskaya E., Cherdyntsev E. Multidimensional Visualization for the Immune System State Presentation in Breast Cancer Patients. 5th International Scientific Conference on New Operational Technologies (NEWOT); 2015, AIP Conf. Proc. 1688, 080003–1–080003–4.
- Biswas S. K., Mantovani A. Macrophages: biology and role in the pathology of diseases. New York: Springer. 2014, 7–11.
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