IMMUNOLOGICAL CORRELATES OF A CANDIDATE DNA VACCINE AGAINST HIV-1 SUBTYPE A

Cover Page


Cite item

Full Text

Abstract

Since 1981, when AIDS was identified as a disease about 60 million of HIV infected people have been registered and 30 million have died according to WHO. The development of vaccines against HIV/AIDS is an important step in solving this problem. In the absence of an adequate animal model for HIV, vaccine development requires an understanding of immunological correlates of HIV protection. In this study we investigated the immunological correlates of a candidate HIV-1 DNA vaccine. We analyzed the specific immune responses in phase I clinical trial participants and in HIV exposed seronegative individuals. In both groups, an increase in TNFα cytokine by CD4+ T cells in response to specific peptide stimulation was found. This could be an indicator of the possible vaccine efficacy.

About the authors

E. B. Akulova

State Research Institute of Highly Pure Biopreparations

Author for correspondence.
Email: e.b.akulova@hpb.spb.ru

Deputy Head of Laboratory of HIV Molecular Biology,

St. Petersburg

Russian Federation

B. V. Murashev

The Biomedical Center

Email: fake@neicon.ru

PhD, Senior Researcher,

St. Petersburg

Russian Federation

O. V. Nazarenko

The Biomedical Center

Email: fake@neicon.ru

Researcher,

St. Petersburg

Russian Federation

S. V. Verevochkin

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Senior Researcher of Laboratory of HIV Molecular Biology, 

St. Petersburg

Russian Federation

A. E. Masharsky

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

PhD, Leading Researcher of Laboratory of HIV Molecular Biology,

St. Petersburg

Russian Federation

R. I. Al Shekhadat

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

PhD, Leading Researcher of Laboratory of HIV Molecular Biology,

St. Petersburg

Russian Federation

D. A. Lioznov

Pavlov First Saint Petersburg State Medical University

Email: fake@neicon.ru

MD, Head of Dept. of Infectious Diseases and Epidemiology, 

St. Petersburg

Russian Federation

A. P. Kozlov

State Research Institute of Highly Pure Biopreparations;
The Biomedical Center

Email: fake@neicon.ru

D. Sc., Prof., Head of Laboratory of HIV Molecular Biology;

Director,

St. Petersburg

Russian Federation

References

  1. Murashev B. V., Nazarenko O. V., Akulova E. B., Artemyeva A. K., Verevochkin S. V., Shaboltas A. V., Skochilov R. V., Toussova O. V., Kozlov A. P. The high frequency of HIV type 1-specific cellular immune responses in seronegative individuals with parenteral and/or heterosexual HIV type 1 exposure. AIDS Res Hum Retroviruses. 2012, 12, 1598–605.
  2. Akulova E., Murashev B., Nazarenko O., Verevochkin S., Masharsky A., Krasnoselskikh T., Lioznov D., Sokolovsky E., Kozlov A. P. Immune Responses Induced by Candidate Optimized HIV DNA Vaccine in Phase I Clinical Trial. Madridge J Vacc. 2017, 1(1), 34–43.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Akulova E.B., Murashev B.V., Nazarenko O.V., Verevochkin S.V., Masharsky A.E., Al Shekhadat R.I., Lioznov D.A., Kozlov A.P.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.