LEVEL OF MATRIX METAL PROTEINAS AND THEIR TISSUE INHIBITORS IN WOMEN WITH NON-CARE OF PREGNANCY

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Abstract

Surveyed 28 patients with sexually transmitted infections (STIs), or papillomavirus infection (PVI). The patients were divided into the main group (FG) and the control group (GC) (n = 10). The main group was divided into 2 groups: Group I (n = 8) ‒ STIs with MWI, Group II (n = 10) ‒ STIs without MWI. A simultaneous increase in MMP-9 and TIMP-1 in the serum of women with miscarriage was established, which indicates the role of the processes of damage to the extracellular matrix in its pathogenesis. Diff erences in the ratio of MMP-9 to TIMP-1 depending on the presence of HPV were revealed. Women with STIs without HPV are dominated by products of TIMP that can have a profibrinogenic eff ect.

About the authors

M. S. Tulupova

FGOAO HE “Russian University of Peoples’ Friendship” of the Ministry of Education of the Russian Federation

Email: fake@neicon.ru

Ph.D., Doctoral Candidate of the Department of Obstetrics and Gynecology with a course of Perinatology,

Vladivostok

Russian Federation

M. B. Hamoshin

FGOAO HE “Russian University of Peoples’ Friendship” of the Ministry of Education of the Russian Federation

Email: fake@neicon.ru

MD, Professor of the Department of Obstetrics and Gynecology with a course in Perinatology,

Vladivostok

Russian Federation

T. A. Nevezhkina

Pacific State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: www.tanya.ru9292@mail.ru

Post-Graduate Student, Department of Normal and Pathological Physiology,

Vladivostok

Russian Federation

O. N. Sidorova

Pacific State Medical University, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

Ph.D., Associate Professor, Department of Normal and Pathological Physiology,

Vladivostok

Russian Federation

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Copyright (c) 2019 Tulupova M.S., Hamoshin M.B., Nevezhkina T.A., Sidorova O.N.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


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