PECULIARITIES OF THE CYTOKINE PROFILE IN CHILDREN WITH BRONCHIAL ASTHMA IN COMBINATION WITH ALLERGIC RHINITIS

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Abstract

We have studied the content of pro-inflammatory and anti-inflammatory cytokines (IL-4, IL-10, IL-13) and level of IFNγ ‒ production in blood serum of 110 children with bronchial asthma aged 3‒11 years old. The control group consisted of 30 healthy children of the same age. The said cytokines were analyzed in blood serum using sandwich ELISA technique and chemical reagents by R&D Diagnostics Inc (USA). Both during remission and exacerbation, levels of IL-4, IL-10, IL-13 in children with BA was found to be signifi cantly higher, and the level of IFNγ – considerably lower. The identifi ed tendency is also typical for children with combined bronchial asthma and allergic rhinitis.

About the authors

A. I. Turyanskya

Federal State Budgetary Educational Institution of Higher Education “Pacific State Medical University” of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: alinakld@mail.ru

Assistant of Department of Clinical Laboratory Diagnostics and General and Clinical Immunology,

Vladivostok 

Russian Federation

V. A. Sabynych

Federal State Budgetary Educational Institution of Higher Education “Pacific State Medical University” of the Ministry of Healthcare of the Russian Federation;
Regional State Budgetary Healthcare Institution “Vladivostok Clinical and Diagnostic Centre”

Email: fake@neicon.ru

Candidate of Medical Sciences, Associate Professor of Department of Clinical Laboratory Diagnostics and General and Clinical Immunology,

Vladivostok 

Russian Federation

References

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  5. Симбирцев А. С. Цитокины в патогенезе и лечении заболеваний человека. СПб: Фолиант, 2018. 512с.

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Copyright (c) 2019 Turyanskya A.I., Sabynych V.A.

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