EARLY CYTOKINE PREDICTORS OF ACUTE REJECTION OF KIDNEY TRANSPLANT

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Abstract

The study of the protective role of blood cytokines evaluated by multiplex analysis before kidney transplantation in recipients with chronic kidney disease showed that the predictors of acute kidney transplant rejection in recipients can be considered high plasma levels of IL-17A, IL-1RA, IL-33, CCL2, as well as BDNF and ccl1 defi ciency. The early signs of a favorable post-transplant period are complete absence or extremely low levels of IL-1β, IL-6, IL-17A, decreased levels of LIF, IL-33, CXCL12), as well as high levels of CXCL8, CXCL10, IFNγ and CCL5.

About the authors

T. V. Fedorenko

“Kuban state medical University” of the Ministry of health care of the Russian Federation;
Regional coordination center of organ donation of the Regional clinical hospital № 1

Author for correspondence.
Email: fake@neicon.ru

post-graduate student of the Department of Clinical immunology, allergology and laboratory diagnostics;

laboratory biologist,

Krasnodar

Russian Federation

N. V. Kolesnikova

“Kuban state medical University” of the Ministry of health care of the Russian Federation

Email: nvk24071954@mail.ru

professor of the Department of Clinical immunology, allergology and laboratory diagnostics,

Krasnodar

Russian Federation

I. A. Pashkova

Regional coordination center of organ donation of the Regional clinical hospital № 1

Email: fake@neicon.ru

professor of the Department of Clinical immunology, allergology and laboratory diagnostics,

Krasnodar

Russian Federation

References

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  4. Lemaître P. H., Vokaer B., Charbonnier L. M. Iwakura Y., Estenne M., Goldman M., Leo O., Remmelink M., Le Moine A. IL-17A mediates early post-transplant lesions after heterotopic trachea allotransplantation in Mice. PloS one, 2013, 8, 7, 70236.
  5. Yin X. T., Zobell S., Jarosz J. G. Stuart P. M. Anti–IL-17 Therapy Restricts and Reverses Late-Term Corneal Allorejection. The Journal of Immunology, 2015, 194, 8. – С. 4029–4038.
  6. Lo D. J., Kaplan B., Kirk A. D. Biomarkers for kidney transplant rejection. Nat Rev Nephrol., 2014, 10, 215– 225.

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Copyright (c) 2019 Fedorenko T.V., Kolesnikova N.V., Pashkova I.A.

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