Email this article THE EFFECT OF ALLOIMMUNIZATION BY HUMAN LYMPHOCYTES ON THE PROLIFERATIVE ACTIVITY OF WOMAN CELLS WITH A HIGH FREQUENCY OF HLA SHARING
- Authors: Fedorova A.V.1, Khonina N.A.2
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Affiliations:
- «Новосибирский национальный исследовательский государственный университет»
- Federal Budget Institution of Science «Research Institute of fundamental and clinical immunology»
- Issue: Vol 22, No 2-1 (2019)
- Pages: 593-595
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/227
- DOI: https://doi.org/10.31857/S102872210006985-8
- ID: 227
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Abstract
The level of the proliferative response of female cells to partner antigens in women with a high degree of HLA sharing in couples is significantly lower than in women with no HLA similarity. The alloimmunization of the partner’s lymphocytes is accompanied by an increase in the proliferative response in all groups of women regardless of HLA sharing. However, woman with a high sharing of HLA antigens have a lower level of cell proliferation than woman with no sharing of HLA antigens.
About the authors
A. V. Fedorova
«Новосибирский национальный исследовательский государственный университет»
Author for correspondence.
Email: fake@neicon.ru
MD, PhD, Leading Researcher of the Laboratory of Сell Immunotherapy,
Novosibirsk
Russian FederationN. A. Khonina
Federal Budget Institution of Science «Research Institute of fundamental and clinical immunology»
Email: nkhonina@mail.ru
student,
Novosibirsk
Russian FederationReferences
- Shankarkumar U., Pawar A., Gaonkar P., Parasannavar D., Salvi V., Ghosh K. HLA allele associations in idiopathic recurrent spontaneous abortion patients from India. J Hum Reprod Sci. 2008, 1, 19–24.
- Cavalcante M. B., Sarno M., Niag M. Lymphocyte immunotherapy for recurrent miscarriages: Predictors of therapeutic success. Am J Reprod Immunol. 2018, 79: e12833. doi: 10.1111/aji.12833.
- Günther V., Alkatout I., Junkers W., Maass N., Ziemann M., Görg S., von Otte S. Active Immunisation with Partner Lymphocytes in Female Patients Who Want to Become Pregnant – Current Status. Geburtshilfe Frauenheilkd. 2018, l78, 260–273. doi: 10.1055/ s-0044-101609.
- Khonina N. A., Broitman E. V., Shevela E. Y., Pasman N. M., Chernykh E. R. Mixed lymphocyte reaction blocking factors (MRL-Bf) as potential biomarker for indication and efficacy of paternal lymphocyte immunization in recurrent spontaneous abortion. Arch Gynecol Obstet. 2013, 288, 933–7.doi: 10.1007/s00404-013-2832-x.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).