Email this article LEVELS OF IL-6 AND IFN-γ IN CHILDREN WITH SCHIZOPHRENIA AND AUTHISM SPECTRUM DISORDERS WITH DIFFERENT PHENOTYPES OF SOCIAL BEHAVIOR
- Authors: Filippova Y.Y.1, Burmistrova A.L.1
-
Affiliations:
- «Chelyabinsk State University»
- Issue: Vol 22, No 2-1 (2019)
- Pages: 599-601
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/229
- DOI: https://doi.org/10.31857/S102872210007012-8
- ID: 229
Cite item
Full Text
Abstract
The paper presents the results of a study of the levels of important regulatory mediators of neurogenesis and neuroplasticity: IL-6 and IFN-γ in the blood plasma of children with schizophrenia and autism spectrum disorders with diff erent phenotypes of social behavior. Children with schizophrenia have been found to have signifi cantly high levels of the cytokines, both in comparison with typically developing children and with children with autism. The heterogeneous group of children with autism, a feature of which is the partial loss of previously acquired social skills – «Regression», is characterized by intermediate IL-6 and IFN-γ values and, as we assume, can include children with schizophrenia.
Keywords
About the authors
Yu. Yu. Filippova
«Chelyabinsk State University»
Author for correspondence.
Email: julse@rambler.ru
PhD, Associate Professor of Department of Microbiology, Immunology and General Biology, Biological Faculty,
Chelyabinsk
Russian FederationA. L. Burmistrova
«Chelyabinsk State University»
Email: fake@neicon.ru
MD, Professor, Head of Department of Microbiology, Immunology and General Biology, Faculty of Biology,
Chelyabinsk
Russian FederationReferences
- Baron-Cohen S. Editorial Perspective: Neurodiversity – a revolutionary concept for autism and psychiatry. J. Child. Psychol. Psychiatry, 2017, 58(6), 744–747.
- Owen M. J., O’Donovan M. C., Thapar A., Craddock N. Neurodevelopmental hypothesis of schizophrenia. Br. J. Psychiatry, 2011, 198(3), 173–175.
- Barlati S., Deste G., Ariu C., Vita A. Autism spectrum disorder and schizophrenia: do they overlap? Int. J. Emerg. Mental Health and Human Res., 2016, 18(1), 760–763.
- Vorstman J. A.S., Burbach J. P.H. Autism and schizophrenia genetic and phenotypic relationships. In book: Comprehensive Guide to Autism. Springer Science & Business Media, New York 2014, P. 1645–1662.
- Goldsmith D. R., Rapaport M. H., Miller B. J. A metaanalysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol. Psychiatry, 2016, 21(12), 1696–1709.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).