Email this article EXPRESSION AND FUNCTIONAL ACTIVITY OF TLR2 AND TLR4 IN PATIENTS WITH ALLERGIC BRONCHIAL ASTHMA
- Authors: Khoreva M.V.1, Latisheva T.V.2, Ogurtsova A.D.1, Gracheva L.A.3, Zakharov M.V.3, Switich O.A.1, Gankovskaya L.V.1
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Affiliations:
- Pirogov Russian National Research Medical University
- National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
- Russian Children’s Clinical Hospital
- Issue: Vol 22, No 2-1 (2019)
- Pages: 614-616
- Section: ORIGINAL ARTICLES
- Submitted: 21.05.2020
- Accepted: 21.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/236
- DOI: https://doi.org/10.31857/S102872210006990-4
- ID: 236
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Abstract
TLR2 and TLR4 expression and functional activity in peripheral blood mononuclear cell of patients with controlled allergic bronchial asthma were increased. TLR2 and TLR4 expression and functional activity in peripheral blood mononuclear cell were higher in patients with moderate asthma than in patients with mild asthma. The identifi ed changes may increase the susceptibility of patients to infectious agents and lead to complications.
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About the authors
M. V. Khoreva
Pirogov Russian National Research Medical University
Author for correspondence.
Email: markhoreva@yandex.ru
PhD, MD (Medicine), Professor of Department of Immunology, Faculty of Medical Biology,
Moscow
Russian FederationT. V. Latisheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head of the Department of Immunopathology and Intensive Therapy,
Moscow
Russian FederationA. D. Ogurtsova
Pirogov Russian National Research Medical University
Email: fake@neicon.ru
assistant of Department of Immunology, Faculty of Medical Biology,
Moscow
Russian FederationL. A. Gracheva
Russian Children’s Clinical Hospital
Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Laboratory of Clinical Immunology,
Moscow
Russian FederationM. V. Zakharov
Russian Children’s Clinical Hospital
Email: fake@neicon.ru
Ph.D., Head of the Department of blood transfusion and gravitational surgery,
Moscow
Russian FederationO. A. Switich
Pirogov Russian National Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Corresponding Member of the Russian Academy of Sciences, Professor of Department of Immunology, Faculty of Medical Biology,
Moscow
Russian FederationL. V. Gankovskaya
Pirogov Russian National Research Medical University
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head of the Department of Immunology, Faculty of Medical Biology,
Moscow
Russian FederationReferences
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- Ковальчук Л. В., Хорева М. В., Никонова А. С. Распознающие рецепторы врожденного иммунитета (NLR, RLR И CLR) // Журнал микробиологии, эпидемиологии и иммунобиологии, 2011. No 1. С. 93–100.
- Bezemer G. F., Sagar S., van Bergenhenegouwen J., Georgiou N. A., Garssen J., Kraneveld A. D., Folkerts G. Dual role of Toll-like receptors in asthma and chronic obstructive pulmonary disease. Pharmacol. Rev., 2012, no. 64, pp. 337–358.
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