EFFECT OF POTENTIAL ANTHELMINTIC DRUGS ON IL-1β EXPRESSION IN EXPERIMENTAL OPISTHORCHIASIS

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Abstract

Interleukin-1 beta (IL-1β) is an indicator of liver infl ammatory processes in opisthorchiasis. Administration of curcumin and new complex of praziquantel with disodium glycyrrhizin ate reduced the parasitic load in O. felineus-infected animals. Moreover, the complex prevented the development of pathomorphological changes and reduced the IL-1β expression in the liver.

About the authors

M. A. Tsyganov

Federal Research Center Institute of Cytology and Genetics, Siberian branch of the Russian academy of sciences

Author for correspondence.
Email: mtzygan@mail.ru

junior researcher of Laboratory of molecular mechanisms of pathological processes ICG SB RAS, 

Novosibirsk

Russian Federation

M. N. Lvova

Federal Research Center Institute of Cytology and Genetics, Siberian branch of the Russian academy of sciences

Email: fake@neicon.ru

junior researcher of Laboratory of molecular mechanisms of pathological processes ICG SB RAS,

Novosibirsk

Russian Federation

A. V. Dushkin

Iinstitute ofsolid state chemistry and mechanochemistry, Siberian branch of the Russian academy of sciences

Email: fake@neicon.ru

Doctor of biology, head of Group of mechanochemistry of organic compounds, ISSC SB RAS,

Novosibirsk

Russian Federation

V. A. Modvinov

Federal Research Center Institute of Cytology and Genetics, Siberian branch of the Russian academy of sciences

Email: fake@neicon.ru

Doctor of biology, head of Laboratory of molecular mechanisms of pathological processes ICG SB RAS,

Novosibirsk

Russian Federation

D. F. Avgustinovich

Federal Research Center Institute of Cytology and Genetics, Siberian branch of the Russian academy of sciences

Email: fake@neicon.ru

Doctor of biology, senior researcher of Laboratory of molecular mechanisms of pathological processes ICG SB RAS,

Novosibirsk

Russian Federation

References

  1. Fedorova O. S., Kovshirina Y. V., Kovshirina A. E., Fedorova M. M., Deev I. A., Petrovskiy F. I., Filimonov A. V., Dmitrteva A. I., Kudyakov L. A., Saltykova I. V., Odermatt P., Ogorodova L. M. Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: a review of medical statistics. Parasitol Int. 2017, 66(4), 365–371.
  2. Tulotta C., Ottewell P. The role of IL-1B in breast cancer bone metastasis. Endocr Relat Cancer. 2018, 25(7), 421–434.
  3. Surapaitoon A., Suttiprapa S., Mairiang E., Khuntikeo N., Pairojkul C., Bethony J., Brindle P. J., Sripa B. Subsets of inflammatory cytokine gene polymorphisms are associated with risk of carcinogenic liver fluke Opisthorchis viverrini-associated advanced periductal fibrosis and cholangiocarcinoma. Korean J Parasitol. 2017, 55(3), 295–304.

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Copyright (c) 2019 Tsyganov M.A., Lvova M.N., Dushkin A.V., Modvinov V.A., Avgustinovich D.F.

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