MYELOID-DERIVED SUPPRESSOR CELLS IN MULTIPLE MYELOMA PATIENTSDURING THE MOBILIZATION OF HEMATOPOETIC STEM CELLS

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Abstract

We investigated the relative content of circulating early (LinCD33+HLA-DR–CD66b), granulocyte (LinCD33+HLA-DR–CD66b+) and monocyte (CD14+HLA-DRlow/–) myeloid-derived suppressor cells (MDSCs) in patients with primary multiple myeloma (MM) at the mobilization of hematopoietic stem cells (HSC). The relative count of all the studied subtypes of MDSCs in patients with both complete remission and partial response did not significantly differ from those in healthy donors. Mobilization of HSCs was not associated with any changes in the content of CD14+HLA-DRlow/– and LinCD33+HLADR–CD66b, however, led to a significant increase in Lin–CD33+HLA-DR–CD66b+. Thus, carrying out the mobilization of HSCs in patients with MM maybe accompanied by the accumulation of granulocyte MDSCs in the autograft. 

About the authors

T. A. Aristova

Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»

Author for correspondence.
Email: ct_lab@mail.ru

postgraduate student,

Novosibirsk

Russian Federation

E. V. Batorov

Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»

Email: fake@neicon.ru

PhD, Researcher,

Novosibirsk

Russian Federation

A. A. Ostanin

Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»

Email: fake@neicon.ru

MD, Chief Researcher, 

Novosibirsk

Russian Federation

References

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  4. Romano A., Parrinello N. L., Vetro C., Forte S., Chiarenza A., Figuera A., Motta G., Palumbo G. A., Ippolito M., Consoli U., Di Raimondo F. Circulating myeloid-derived suppressor cells correlate with clinical outcome in Hodgkin Lymphoma patients treated up-front with a risk-adapted strategy. Br J Haematol. 2015,168(5), 689–700.

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Copyright (c) 2019 Aristova T.A., Batorov E.V., Ostanin A.A.

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