ANALYSIS OF PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF SUPPRESSOR POPULATIONS IN BRONCHIAL ASTHMA

J. A. Shevchenko; Шевченко Ю. А.; M. S. Kuznetsova; Кузнецова М. С.; Yu. A. Lopatnikova; Лопатникова Ю. А.; D. V. Demina; Демина Д. В.; J. A. Sennikova; Сенникова Ю. А.; O. P. Vorobyova; Воробьева О. П.

doi:10.31857/S102872210007003-8

ANALYSIS OF PHENOTYPIC AND FUNCTIONAL CHARACTERISTICS OF SUPPRESSOR POPULATIONS IN BRONCHIAL ASTHMA

Authors: Shevchenko J.A.¹, Kuznetsova M.S.¹, Lopatnikova Y.A.¹, Demina D.V.¹, Sennikova J.A.², Vorobyova O.P.¹^,3
Affiliations:
1. Research Institute of Fundamental and Clinical Immunology
2. Novosibirsk State Medical University
3. Novosibirsk National Research State University
Issue: Vol 22, No 2-1 (2019)
Pages: 650-652
Section: ORIGINAL ARTICLES
Submitted: 25.05.2020
Accepted: 25.05.2020
Published: 15.04.2019
URL: https://rusimmun.ru/jour/article/view/250
DOI: https://doi.org/10.31857/S102872210007003-8
ID: 250

Cite item

Full Text

Abstract
About the authors
References
Supplementary files
Statistics

Abstract

In patients with atopic allergic diseases, the number or functional characteristics of T-regulatory cells may be insufficient. The determination of the phenotypic characteristics of T-regulatory cells also makes a significant contribution to such a large variety of data obtained. The main difficulties in finding correlations between suppressor populations and the development of pathogenetic processes: the absence of a well-defined set of markers for T-regulatory cells, dependence on the stage of the disease, the duration of taking glucocorticosteroids and other drugs. No less important in studying the involvement of T-regulatory cells in the development of pathological reactions is not only the analysis of the content of T-regulatory cells, but also the assessment of their functional activity, the level of expression of membrane-bound functional molecules and the production of soluble factors by them.