IMBALANCE IN THE CONTENT OF CYTOKINES AND GROWTH FACTORS IN THE INTRAOCULAR FLUID IN PRIMARY OPEN-ANGLE GLAUCOMA

Cover Page
  • Authors: Ermakova O.V.1, Orlov N.B.2, Trunov A.N.1,3, Konenkov V.I.2, Chernykh V.V.1
  • Affiliations:
    1. The academician S. N. Fyodorov Federal State Institution National Medical Research Center «Intersectoral Research and Technology Complex «Eye microsurgery» Ministry of Health of the Russian Federation»
    2. Scientific Research Institute of Clinical and Experimental Lymphology – a branch of Federal Research Center of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»
    3. Federal Research Center for Fundamental and Translational Medicine of the Siberian Branch of the Russian Academy of Sciences»
  • Issue: Vol 22, No 2-2 (2019)
  • Pages: 769-771
  • Section: ORIGINAL ARTICLES
  • Submitted: 03.06.2020
  • Accepted: 03.06.2020
  • Published: 15.07.2019
  • URL: https://rusimmun.ru/jour/article/view/295
  • DOI: https://doi.org/10.31857/S102872210006704-9
  • ID: 295


Cite item

Full Text

Abstract

Was shown increase in the concentrations of cytokines and growth factors (IL-4, IL-6, IL-8, IL-17, TGF-β -1, 2, 3, macrophage infl ammatory protein – 1beta) in the intraocular fluid of patients withdevelopedstage of the primary open-angle glaucoma. This indicates that in the pathogenesis of primary open-angle glaucoma, the activity of the local chronic inflammatory process is determined.

About the authors

O. V. Ermakova

The academician S. N. Fyodorov Federal State Institution National Medical Research Center «Intersectoral Research and Technology Complex «Eye microsurgery» Ministry of Health of the Russian Federation»

Author for correspondence.
Email: oven_e@mail.ru

врач-офтальмолог Новосибирского филиала,

630096, г. Новосибирск, ул. Колхидская д. 10

Russian Federation

N. B. Orlov

Scientific Research Institute of Clinical and Experimental Lymphology – a branch of Federal Research Center of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»

Email: fake@neicon.ru

к. м. н., старший научный сотрудник лаборатории иммуногенетики,

 

Russian Federation

A. N. Trunov

The academician S. N. Fyodorov Federal State Institution National Medical Research Center «Intersectoral Research and Technology Complex «Eye microsurgery» Ministry of Health of the Russian Federation»;
Federal Research Center for Fundamental and Translational Medicine of the Siberian Branch of the Russian Academy of Sciences»

Email: fake@neicon.ru

д. м. н., профессор, заместитель директора по научной работе Новосибирского филиала,

главный научный сотрудник лаборатории иммунологии,

Новосибирск

Russian Federation

V. I. Konenkov

Scientific Research Institute of Clinical and Experimental Lymphology – a branch of Federal Research Center of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences»

Email: fake@neicon.ru

д. м. н., профессор, академик РАН, заведующий лабораторией клинической иммуногенетики,

Новосибирск

Russian Federation

V. V. Chernykh

The academician S. N. Fyodorov Federal State Institution National Medical Research Center «Intersectoral Research and Technology Complex «Eye microsurgery» Ministry of Health of the Russian Federation»

Email: fake@neicon.ru

д. м. н., профессор, директор Новосибирского филиала,

Новосибирск

Russian Federation

References

  1. Черных В. В., Бгатова Н. П., Орлов Н. Б., Ермакова О. В., Трунов А. Н. Местный воспалительный процесс при глаукоме как возможное проявление нарушений увеолимфатического оттока внутриглазной жидкости при глаукоме. Национальный журнал глаукома. 2018. 17(2). 3–11.
  2. Junglas B., Kuespert S., Seleem A. A., Struller T., Ullmann S., Bösl M., Bosserhoff A., Köstler J., Wagner R., Tamm E. R., Fuchshofer R.Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork Am. J. Pathol. 2012. 180(6). 2386–2403.
  3. Kokubun T., Tsuda S., Kunikata H., Yasuda M., Himori N., Kunimatsu-Sanuki S., Maruyama K., Nakazawa T. Characteristic profiles of inflammatory cytokines in the aqueous humor of glaucomatous eyes. Ocul. Immunol. Infl amm. –2017. 16. 1–12.
  4. Tong Y., Zhou Y. L., Zheng Y., Biswal M., Zhao P. Q., Wang Z. Y. Analyzing cytokines as biomarkers to evaluate severity of glaucoma. Int. J. Ophthalmol. – 2017. 10(6). 925–930.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Ermakova O.V., Orlov N.B., Trunov A.N., Konenkov V.I., Chernykh V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies