Email this article FACTORS OF IMMUNOENDOCRINE REGULATION IN ALCOHOL DEPENDENCE AT THE STAGE OF FORMATION OF THERAPEUTIC REMISSION
- Authors: Vetlugina T.P.1, Nikitina V.B.1, Mandel A.I.1, Boiko A.S.1, Prokopieva V.D.1, Bokhan N.A.1
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Affiliations:
- Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- Issue: Vol 22, No 2-1 (2019)
- Pages: 183-186
- Section: ORIGINAL ARTICLES
- Submitted: 13.04.2020
- Accepted: 13.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/38
- DOI: https://doi.org/10.31857/S102872210006447-6
- ID: 38
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Abstract
The aim of the study was to study the dynamics of the immunoendocrine factors in patients with alcohol dependence in the process of therapy of withdrawal syndrome and post-withdrawal state. In 35 men with alcohol dependence in the dynamics of formation of therapeutic remission, the level of spontaneous production of spectrum of cytokines by immunocompetent cells was investigated; in the blood serum – hormones. Control – 19 practically healthy men. Hyperproduction of proinfl ammatory cytokines, increase in the concentration of cortisol, decrease in the concentration of T3 and T4 were established. Dependence of IFNγ, IL-1ra, IL-2 and testosterone on character of remission was revealed that allows considering these factors as candidates into biomarkers of prediction of the stability of remission.
About the authors
T. P. Vetlugina
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Author for correspondence.
Email: vetlug@mail.tomsknet.ru
D. Sc., Prof., lead researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology, Head of the Department of Biological Psychiatry and Narcology,
Tomsk
Russian FederationV. B. Nikitina
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
MD, Head of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology,
Tomsk
Russian FederationA. I. Mandel
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
MD, Prof., lead researcher of Addictive States Department,
Tomsk
Russian FederationA. S. Boiko
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD, researcher of the Laboratory of Molecular Genetics and Biochemistry,
Tomsk
Russian FederationV. D. Prokopieva
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
D. Sc., lead researcher of Laboratory of Clinical Psychoneuroimmunology and Neurobiology, Head of the Department of Biological Psychiatry and Narcology,
Tomsk
Russian FederationN. A. Bokhan
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
MD, Prof., academician of RAS, Head of Addictive States Department, Director,
Tomsk
Russian FederationReferences
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