MODEL OF INFLUENCE HYPOSCIAS ON THE CELLULAR COMPONENT AND SYNTHESIS COMPONENTS EXTRACELLULAR MATRIX IN CULTURE FIBROBLASTS

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Abstract

It is established, that cultivation fibroblasts in conditions hypoxia leads to decrease in their morphological heterogeneity, increase proliferative to activity and viability of cells. Causes oppression of synthesis of components extracellular matrix (collagen and elastin) and decrease expression a receptor hyaluronic acids (CD44). Duration hypoxia causes a degree of decrease.

About the authors

U. G. Suhovej

«Tyumen filial of the Institute Clinical Immunology»

Author for correspondence.
Email: fake@neicon.ru

MD (Medicine), Professor, Director,

Tyumen

Russian Federation

E. G. Kostolomova

«Tyumen filial of the Institute Clinical Immunology»;
FSBEI of Higher Education «Tyumen state medical university» of the Ministry
of Healthcare of Russian Federation

Email: lenakost@mail.ru

PhD (Biology), the assistant to faculty of pathological physiology,

Tyumen

Russian Federation

I. G. Unger

«Tyumen filial of the Institute Clinical Immunology»

Email: fake@neicon.ru

PhD (Medicine), leading research associate,

Tyumen

Russian Federation

T. V. Akuneeva

«Tyumen filial of the Institute Clinical Immunology»

Email: fake@neicon.ru

senior research associate,

Tyumen

Russian Federation

I. A. Aptekar’

ANO «Tyumen institute of manual medicine»

Email: fake@neicon.ru

PhD (Medicine), Director,

Tyumen

Russian Federation

References

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  2. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D., Deans R., Keating A., Prockop D. J., Horwitz E. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4):315–7
  3. Кудрявцев И. В., Хайдуков С. В., Зурочка А. В., Черешнев В. А. Применение метода проточной цитофлуориметрии для оценки пролиферативной активности клеток в медико-биологических исследованиях. Российский иммунологический журнал, 2012; 6(14), № 3–1:21–40.

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Copyright (c) 2019 Suhovej U.G., Kostolomova E.G., Unger I.G., Akuneeva T.V., Aptekar’ I.A.

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