Email this article FUNCTIONAL POLYMORPHISMS OF THE TNFα (G-308A), IL-1β (T-31C), IL-10 (C-592A) GENES AS FACTORS AFFECTING THE EFFECT OF CHEMOTHERAPY FOR ADVANCED OVARIAN CANCER
- Authors: Gening S.O.1, Abakumova T.V.1, Antoneeva I.I.1,2, Gening T.P.1, Dolgova D.R.1
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Affiliations:
- Ulyanovsk State University
- Ulyanovsk Regional Clinical Oncologic Dispensary
- Issue: Vol 22, No 2-1 (2019)
- Pages: 197-199
- Section: ORIGINAL ARTICLES
- Submitted: 13.04.2020
- Accepted: 13.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/43
- DOI: https://doi.org/10.31857/S102872210006455-5
- ID: 43
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Abstract
The paper discusses the role of a genetically determined imbalance in the cytokine network in assessing the eff ectiveness of platinum-containing chemotherapy in patients with serous ovarian adenocarcinoma. The frequency of functional polymorphisms of the cytokine IL-1β (T-31C), TNFα (G-308A), IL-10 (G-592A) genes was determined by qRT-PCR in control and in patients with advanced ovarian cancer. We studied the frequency distribution of alleles and genotypes of the IL-1β, TNFα, IL-10 genes in patients with OC in groups with relapses within a year after platinum-containing chemotherapy and without recurrence. The alleles -308G TNFα, -31T IL-1β, -592A IL-10 were found to be associated with disease progression or recurrence within 1 year after completion of treatment.
About the authors
S. O. Gening
Ulyanovsk State University
Author for correspondence.
Email: fake@neicon.ru
postgraduate student, Department of Oncology and Radiology,
Ulyanovsk
Russian FederationT. V. Abakumova
Ulyanovsk State University
Email: fake@neicon.ru
PhD, Associate Professor, Department of Physiology and Pathophysiology, Medical Faculty,
Ulyanovsk
Russian FederationI. I. Antoneeva
Ulyanovsk State University;Ulyanovsk Regional Clinical Oncologic Dispensary
Email: fake@neicon.ru
MD, Professor, Department of Oncology and Radiology,
Ulyanovsk
Russian FederationT. P. Gening
Ulyanovsk State University
Email: fake@neicon.ru
Doctor of Biological Sciences, Professor, Head of Department Physiology and Pathophysiology of the Medical Faculty,
Ulyanovsk
Russian FederationD. R. Dolgova
Ulyanovsk State University
Email: dolgova.dinara@yandex.ru
Ph.D., Associate Professor, Department of Physiology and Pathophysiology, Medical Faculty,
Ulyanovsk
Russian FederationReferences
- Oliveira de J. G., Rossi A. F., Nizato D. M., Silva A. E. Profi les of Gene Polymorphisms in Cytokines and Toll-Like Receptors with Higher Risk for Gastric Cancer. Dig Dis Sci. 2013, 58, 978–988.
- Боброва О. П., Шнайдер Н. А., Петрова М. М., Зырянов С. К., Сычев Д. А. Генетический полиморфизм цитокинов как предиктор фенотипической реализации хронического болевого синдрома в онкологии. Сибирский онкологический журнал. 2017, 16(5), 87–94.
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