Email this article THYMUS IN AUTOIMMUNE DISEASES CLINIC. THE ACTUALITY AND PROSPECTIVES OF “IN VIVO” MONITORING
- Authors: Goloviznin M.V.1, Lakhonina N.S.1, Timofeev V.T.2, Buldakova Y.R.1
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Affiliations:
- A.I Evdokimov Moscow State University of Medicine and Dentistry
- N.I.Pirogov Russian Scientifi c-Research State Medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 208-211
- Section: ORIGINAL ARTICLES
- Submitted: 13.04.2020
- Accepted: 13.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/47
- DOI: https://doi.org/10.31857/S102872210006460-1
- ID: 47
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Abstract
The leading role of Thymus in adoptive immunity development was established 50 years ago. Nevertheless T-cells immunity monitoring in clinical immunology is now testing of growing number of “immune periphery” items disregarding thymus as a central T-immunity organ. We showed that T-cells rearrangement excision circles (TREC) could be the important chain in thymus and peripheral T-cells function assessment in adult and aged healthy donors and rheumatoid arthritis patients. It will create the possibility to form more complex “in vivo” monitoring of thymus activity in autoimmunity.
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About the authors
M. V. Goloviznin
A.I Evdokimov Moscow State University of Medicine and Dentistry
Author for correspondence.
Email: ordinatormgmsu@mail.ru
PhD, Associate professor of the Department of Internal Diseases of dental faculty,
Moscow
Russian FederationN. S. Lakhonina
A.I Evdokimov Moscow State University of Medicine and Dentistry
Email: fake@neicon.ru
Assistant professor of the Department of Internal Diseases of dental faculty,
Moscow
Russian FederationV. T. Timofeev
N.I.Pirogov Russian Scientifi c-Research State Medical University
Email: fake@neicon.ru
D. Sci, Leading researcher of Faculty therapy department,
Moscow
Russian FederationYu. R. Buldakova
A.I Evdokimov Moscow State University of Medicine and Dentistry
Email: fake@neicon.ru
PhD, Associate professor of the Department of Internal Diseases of dental faculty,
Moscow
Russian FederationReferences
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- Донецкова А. Д., Ярилин А. А. T-рецепторные эксцизионные кольца и значимость их определения в клинике // Иммунология. – 2013. – № 4. – С. 220– 226.
- Ярилин А. А. Основы иммунологии. – Москва: «Медицина», 1999 г. – 608 с.
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