BIOFLAVONOIDS EFFICIENCY IN EXPERIMENTAL ALCOHOLISM

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Abstract

The prolonged alcohol consumption has a negative effect on the immune and nervous systems, causing a breakdown in their functional connections. The purpose of this work was to study the effect of turmeric bioflavonoids on the behavior and the cellular immune response in animals in a state of experimental alcoholism. It was found that in chronic ethanol intoxication, the use of turmeric extract led to the stimulation of motor and exploratory activity in the «open field» test and an increase in the cellular immune response to the level peculiar to that of healthy animals of a corresponding age, indicating a positive effect of turmeric in experimental alcoholism.

About the authors

I. A. Goldina

Federal State Budgetary Scientific Research Institute of the fundamental and clinical immunology

Author for correspondence.
Email: fake@neicon.ru

Researcher of the Neuroimmunology laboratory,

Novosibirsk

Russian Federation

E. V. Markova

Federal State Budgetary Scientific Research Institute of the fundamental and clinical immunology;
Federal State Budgetary Educational Institution of Higher Education «Novosibirsk State Pedagogical University»

Email: fake@neicon.ru

Doctor of Medical Sciences, Head of the Neuroimmunology laboratory, Chief Researcher;

Professor,

Novosibirsk

Russian Federation

I. V. Savkin

Federal State Budgetary Scientific Research Institute of the fundamental and clinical immunology

Email: fake@neicon.ru

Researcher of the Neuroimmunology laboratory,

Novosibirsk

Russian Federation

References

  1. Гольдина И. А., Маркова Е. В., Гольдин Б. Г., Княжева М. А., Гайдуль К. В. Протекторные свойства куркумы при этанол-индуцированных нарушениях поведения. Саратовский научно-медицинский журнал. 2017, 13(1), 131–135.
  2. Гольдина И. А., Гольдин Б. Г., Гайдуль К. В. Клиническая эффективность куркумы при заболеваниях нервной системы. Нейроиммунология. 2015, XVII(2), 265.
  3. Гольдина И. А., Гайдуль К. В. Биологическая активность и терапевтические свойства Curcuma Longa L. (обзор литературы). Вестник НГУ. 2015, 13(1), 141–149.
  4. Чухрова М. Г., Дресвянников В. Л., Маркова Е. В. Наркотическая зависимость: современные стратегии исследования. Saint-Louis, Missouri, USA: Publishing House Science and Innovation Center, 2015. –218 с.
  5. Markova E. V., Obukhova L. A., Kolosova N. G. Parameters of cell immune response in Wistar and OXYS rats and their behavior in the open fi eld test. Bulletin of Experimental Biology and Medicine. 2003, 136(6), 588–590.

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Copyright (c) 2019 Goldina I.A., Markova E.V., Savkin I.V.

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