THE CONTENTS OF CYTOKINES IN SEMEN IN INFERTILITY ASSOCIATED WITH CHRONIC PROSTATITIS

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Abstract

The study assessed using the ELISA method the content of 16 cytokines in seminal plasma of 85 patients with chronic prostatitis and concomitant infertility in order to determine their significance as potential markers of prognosis and treatment efficacy. A statistically significant increase in the concentration of IFN-γ and IL-18 was established against the background of a significant decrease in the levels of IL-1β, TGF-β, SDF-1α and IL-7. The most informative predictor of the limitation of the fertilizing ability of spermatozoa in inflammation of the prostate gland is the imbalance of IL-18 and TGF-β as key regulators of the immune status of the reproductive system.

About the authors

E. F. Galimova

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: fake@neicon.ru

MD, Leading Researcher of the Central Research Laboratory,

Ufa

Russian Federation

O. Yu. Travnikov

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

Ph.D., Associate Professor, Department of Mobilization Preparation of Public Health and Disaster Medicine,

Ufa

Russian Federation

Z. G. Khaibullina

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

Ph.D., Associate Professor of the Department of Biological Chemistry,

Ufa

Russian Federation

A. Z. Murtazina

State public health institution Medical Information and Analytical Center of the Ministry of Health of the Republic of Bashkortostan

Email: fake@neicon.ru

PhD, Head of Department,

Ufa

Russian Federation

T. S. Asadullina

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

Assistant, Department of Therapy and Nursing,

Ufa

Russian Federation

Sh. N. Galimov

Federal State Budgetary Educational Institution of Higher Education “Bashkir State Medical University” of the Ministry of Healthcare of the Russian Federation

Email: sngalim@mail.ru

MD, Professor, Head of the Department of Biological Chemistry,

Ufa

Russian Federation

References

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Copyright (c) 2019 Galimova E.F., Travnikov O.Y., Khaibullina Z.G., Murtazina A.Z., Asadullina T.S., Galimov S.N.

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