Email this article THE ROLE OF THE MONOCYTIC AND MACROPHAGAL SYSTEM IN THE DYNAMICS OF THE REPLACEMENT REGENERATION IN CASE OF THE ELASTIN BIOMATERIAL TRANSPLANTATION
- Authors: Nigmatullin R.T.1, Gizatullina E.R.1, Motygullin B.R.1
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Affiliations:
- The Russian Eye and Plastic Surgery Centre of the Russian Federation Health Ministry
- Issue: Vol 20, No 2 (2017)
- Pages: 179-182
- Section: Articles
- URL: https://rusimmun.ru/jour/article/view/618
- ID: 618
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Abstract
The article contains the results of the morphological investigations when subcutaneously transplanting two types of the elastin biomaterial: structurized and dispersed one (patent № 2440148). The experiments have been carried out on Wistar rats (n=59). The transplanted biomaterials were subjected to the stage-by-stage resorption with further formation of the connective tissue regenerate. When doing it, the cells of the macrophagal and fibroblastic differentiation come out as a unified morphofunctional system in which giant multinuclear cells are an indispensable element. Depending on the biomaterial structure there are singled out two histotopographic types of the replacement regeneration: frontal type for the structurized biomaterial and diffuse-locunar one for the dispersed biomaterial.
About the authors
R. T. Nigmatullin
The Russian Eye and Plastic Surgery Centre of the Russian Federation Health Ministry
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
E. R. Gizatullina
The Russian Eye and Plastic Surgery Centre of the Russian Federation Health Ministry
Email: noemail@neicon.ru
Russian Federation
B. R. Motygullin
The Russian Eye and Plastic Surgery Centre of the Russian Federation Health Ministry
Email: noemail@neicon.ru
Russian Federation
References
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- Derricks K. E., Rich C. B., Buczek-Thomas J.A., Nugent M. A. Ascorbate enhances elastin synthesis in 3D tissue-engineered pulmonary fibroblasts constructs. Tissue and Cell 2013, 45, 253-260.
- Нигматуллин Р. Т., Кутушев Р. З. Применение эластинового биоматериала в восстановительной хирургии стенок глазницы. «Практическая медицина» 2016, 6(98), 119-121.
- Мулдашев Э. Р., Нигматуллин Р. Т., Галимова В. У. и др. Пат. РФ № 2440148 // Бюл. изобр. 2012.№ 2
- Бабаева А. Г. Регенерация: факты и перспективы. Издательство РАМН, Москва, 2009, 336.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).