THE LOCAL IMMUNE RESPONSE IN PATIENTS AT EARLY POST-SURGERY PERIOD AFTER DENTAL IMPLANTATION DEPENDING ON THE SCHEMES OF ANTIBACTERIAL TREATMENT

Successful performing of dental implantation is one of the major aims of dentistry. Surgery induces violation of the integrity of the mucosa, activation of the mucosal immunity, reparation and regulation processes, that can be measured by levels of IgM, IgG, sIgA and also IL-φ, IL-4, IL-6, IL-10, IL-17A, IFN-γ, TNF-α on the local or systemic level. Some antibiotics and phytotherapy can be applied to prevent potential onset of postoperative complications. Differences in its efficiency and action on the mucosal immunity can be measured with comparative assay of the features of the local immunity in the saliva of patients before dental implantation and after applying the therapies. Application of antibiotics leads to decreasing activity of pathogenic microorganisms and reparative potential of the mucosa cells, that is manifested in statistically significant reduction of the IgG and increased IgM and sIgM levels, whereas phytotherapy enhances activity of the immune system due to stimulation of marked increase in the level of IL-4, IL-10, IFN-γ and TNF-α in the patients' saliva.

Дентальная имплантация, мукозальный иммунитет, фитотерапия, ан-тибиотикотерапия, профилактика послеоперационных осложнений, Dental implantation, mucosal immunity, phytotherapy, antibioticotherapia, prevention of postoperative complications