THE PROLONGATED EFFECTS OF BETA-ENDORPHIN ON MOUSE IL-1BETA, IL-2, IL-4 AND IL-10 SECRETION IN VIVO

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Abstract

Beta-endorphin is a compound of peptide nature with a high regulatory activity on the immune system. The existence of long-term immunoregulatory effects of beta-endorphin is of great interest.This work describes the beta-endorphin effects on the corticosterone levels in plasma, as well as the production of key regulatory cytokines by murine splenocytes and macrophages. The dependence of the beta-endorphin effects from the used dose and exposure time was shown.

About the authors

T. A. Baeva

Institute of Ecology and Genetics of Microorganisms

Author for correspondence.
Russian Federation

S. P. Tendryakova

Institute of Ecology and Genetics of Microorganisms; Perm State University

Russian Federation

References

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  3. Фримель Г. Иммунологические методы. Издательство «Медицина», 1987; 472 с.
  4. Гейн С. В., Баева Т. А., Небогатиков В. О., Тендрякова С. П. Влияние бета-эндорфина на антителогенез, пролиферацию и секрецию Tх1/Tх2-цитокинов in vivo. Бюллетень экспериментальной биологии и медицины, 2011, 11,526-529.

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Copyright (c) 2017 Baeva T.A., Tendryakova S.P.

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