Email this article THE PROLONGATED EFFECTS OF BETA-ENDORPHIN ON MOUSE IL-1BETA, IL-2, IL-4 AND IL-10 SECRETION IN VIVO
- Authors: Baeva T.A.1, Tendryakova S.P.1,2
-
Affiliations:
- Institute of Ecology and Genetics of Microorganisms
- Perm State University
- Issue: Vol 20, No 2 (2017)
- Pages: 246-248
- Section: Articles
- URL: https://rusimmun.ru/jour/article/view/640
- ID: 640
Cite item
Full Text
Abstract
Beta-endorphin is a compound of peptide nature with a high regulatory activity on the immune system. The existence of long-term immunoregulatory effects of beta-endorphin is of great interest.This work describes the beta-endorphin effects on the corticosterone levels in plasma, as well as the production of key regulatory cytokines by murine splenocytes and macrophages. The dependence of the beta-endorphin effects from the used dose and exposure time was shown.
Keywords
About the authors
T. A. Baeva
Institute of Ecology and Genetics of Microorganisms
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
S. P. Tendryakova
Institute of Ecology and Genetics of Microorganisms; Perm State University
Email: noemail@neicon.ru
Russian Federation
References
- Smith M. E. Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis. Brain Behav. Immun. 2008, 22, 3-14.
- Sunal R., Tuncel N., Sumer N. Effect of beta-endorphin and cold stress on heart noradrenalin levels in rats. Ann. N. Y. Acad. Sci. 1987, 496, 158-160.
- Фримель Г. Иммунологические методы. Издательство «Медицина», 1987; 472 с.
- Гейн С. В., Баева Т. А., Небогатиков В. О., Тендрякова С. П. Влияние бета-эндорфина на антителогенез, пролиферацию и секрецию Tх1/Tх2-цитокинов in vivo. Бюллетень экспериментальной биологии и медицины, 2011, 11,526-529.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).