DIFFERENTIATION OF T-CELLS UNDER PRIVACY PREGNANCY OF PREGNANCY IN WOMEN OF CHELYABINSK REGION

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Abstract

Habitual miscarriage of pregnancy (HMP) is one of the leading positions in female infertility. The analysis of T cell differentiation in peripheral blood in patients with HMP has been carried out. A significant increase in the absolute amount of CD45RA+ CD62L+ (Tn) of naive CD4+ and CD8+ lymphocytes was established with a simultaneous increase in the absolute amount of CD45RA-CD62L- (Tem) СD8+ effector cells in patients with HMP compared to the control group. The obtained data require further study and prove the role of the immune system during the gestational process.

About the authors

I. L. Baturina

Medical State University of Chelyabinsk; Institute of Immunology

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

Yu. V. Loginova

Medical State University of Chelyabinsk; Institute of Immunology

Email: noemail@neicon.ru
Russian Federation

M. A. Zotova

Medical State University of Chelyabinsk; Institute of Immunology

Email: noemail@neicon.ru
Russian Federation

V. S. Novozhenina

Medical State University of Chelyabinsk; Institute of Immunology

Email: noemail@neicon.ru
Russian Federation

E. V. Kokh

Medical State University of Chelyabinsk; Institute of Immunology

Email: noemail@neicon.ru
Russian Federation

References

  1. Кудряшова А. В., Краткое сообщение. Дифференцировка СD8+ клеток памяти при беременности// российский иммунологический журнал,- 2014, том 8(17), № 1, с. 79-82.
  2. Сотникова Н. Ю., Формирование феномена иммунологической памяти в динамике гестационного процесса // Российский иммунологический журнал,- 2010, том 4(13), № 4, с. 321-326.
  3. Gammill H. S., Nelson J. L. Naturally acquired micro-chimerism. Int. J. Dev. Biol. 2010,54 (2-3), 531-543.
  4. Erlebacher A., Vencato D., Price K. A., Zhang D., Glimcher L. H. Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J. Clin. Invest. 2010, 117, 1399-1411.

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Copyright (c) 2017 Baturina I.L., Loginova Y.V., Zotova M.A., Novozhenina V.S., Kokh E.V.

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