IMBALANCE OF CHEMOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF MALE INFERTILITY

E. F. Galimova; Галимова Э. Ф.; A. R. Gaysina; Гайсина А. Р.; O. Yu. Travnikov; Травников О. Ю.; K. V. Bulygin; Булыгин К. В.; G. H. Akhmadullina; Ахмадуллина Г. Х.; S. N. Galimov; Галимов Ш. Н.

IMBALANCE OF CHEMOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF MALE INFERTILITY

Authors: Galimova E.F.¹, Gaysina A.R.¹, Travnikov O.Y.¹, Bulygin K.V.¹, Akhmadullina G.H.¹, Galimov S.N.¹
Affiliations:
1. Bashkir State Medial University
Issue: Vol 20, No 2 (2017)
Pages: 273-275
Section: Articles
URL: https://rusimmun.ru/jour/article/view/652
ID: 652

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Abstract

The aim of study was to evaluate the role of chemokines and growth factors in the development of idiopathic infertility. In serum and seminal plasma of the infertile men the deficit and the imbalance of stromal cell factors SDF-1α and transforming growth factor TGFβ, spermatogenesis and modulators of the immune response in the reproductive system are identified. Possible mechanisms for the negative impact of the identified features of the cytokine profile on the fertilizing capacity of sperm were discussed.

Keywords

бесплодие, сперма, хемокины, ростовые факторы, infertility, sperm, chemokines, growth factors

References

Kashanian J., Brannigan R. Male Infertility. Robert E Brannigan 37.76 · 371.39 Northwestern UniversityJAMA 2015, 313, 1770.
Павлов В. Н., Галимова Э. Ф., Терегулов Б. Ф., Кайбышев В. Т., Галимов. Молекулярные и метаболические аспекты мужского бесплодия. Вестник урологии 2016, 2, 40-59.
Wang J., Knaut H. Chemokine signaling in development and disease. Development 2014, 141, 4199-4205.
Fijak M., Bhushan S., Meinhardt A. Immunoprivileged sites: the testis. Methods Mol. Biol 2011, 677, 459-470.
Sharkey D., Macpherson A., Tremellen K. TGF-β Mediates Proinflammatory Seminal Fluid Signaling in Human Cervical Epithelial Cells. J. Immunol. 2012, 189 (2), 1024-1035.

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IMBALANCE OF CHEMOKINES AND GROWTH FACTORS IN THE PATHOGENESIS OF MALE INFERTILITY

Full Text

Abstract

Keywords

About the authors

E. F. Galimova

A. R. Gaysina

O. Yu. Travnikov

K. V. Bulygin

G. H. Akhmadullina

S. N. Galimov

References

Supplementary files

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