Email this article MOLECULAR MODELLING OF FLAVONOID QUERCETIN TARGETING TO THE TOLL-LIKE RECEPTORS
- Authors: Zaitsev V.G.1, Zheltova A.A.2, Nikonenko A.A.1
-
Affiliations:
- Volgograd State University
- Volgograd State Medical University
- Issue: Vol 20, No 2 (2017)
- Pages: 317-319
- Section: Articles
- Submitted: 22.10.2020
- Published: 15.04.2017
- URL: https://rusimmun.ru/jour/article/view/671
- ID: 671
Cite item
Full Text
Abstract
Molecular modelling of quercetin targeting to the extracellular and cytosolic domains of human Tolllike receptors (TLR1-TLR10) was performed. We showed that quercetin can be targeted to various TRLs preferably either in extracellular domain sites (TLR4, TLR5, TLR7, TLR8) or in cytosolic domain sites (TLR1-TLR2, TLR2-TLR6).
About the authors
V. G. Zaitsev
Volgograd State University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. A. Zheltova
Volgograd State Medical University
Email: noemail@neicon.ru
Russian Federation
A. A. Nikonenko
Volgograd State University
Email: noemail@neicon.ru
Russian Federation
References
- Tartey S., Takeuchi O. Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells. Int. Rev. Immunol. 2017, 36(2), 57-73.
- Chen L., Yu J. Modulation of Toll-like receptor signaling in innate immunity by natural products. Int. Immunopharmacol. 2016, 37, 65-70.
- Perez-Cano F.J., Massot-Cladera M., Rodriguez-Lagunas M.J., Castell M. Flavonoids affect host-micro-biota crosstalk through TLR modulation. Antioxi-dants (Basel) 2014, 3(4), 649-670.
- Bhaskar S., Helen A. Quercetin modulates toll-like receptor-mediated protein kinase signaling pathways in oxLDL-challenged human PBMCs and regulates TLR-activated atherosclerotic inflammation in hypercholesterolemic rats. Mol. Cell. Biochem. 2016, 423(1-2), 53-65.
- Chen Y. C. Beware of docking! Trends Pharmacol. Sci. 2015, 36(2), 78-95.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).