Email this article HORIONIC GONADOTROPIN IN REGULATION OF THE FUNCTIONAL ACTIVITY OF T-REGULATORY LYMPHOCYTES
- Authors: Zamorina S.A.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Perm State National Research University
- Issue: Vol 20, No 2 (2017)
- Pages: 319-321
- Section: Articles
- Submitted: 22.10.2020
- Published: 15.04.2017
- URL: https://rusimmun.ru/jour/article/view/672
- ID: 672
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Abstract
The effect of human chorionic gonadotropin (HCG) on apoptosis and production of IL-10 and TGF-β1 by isolated pools of natural T-regulatory lymphocytes (nTreg, CD4+CD25bright) and precursors of adaptive Treg (aTreg, CD4+CD25-) in the in vitro system was studied. As a result, we demonstrated that HCG induces apoptosis of nTreg and interferes with aTreg apoptosis, without affecting the production of IL-10 and TGF-β1 by these cells.
About the authors
S. A. Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
References
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- Schumacher A., Heinze K., Witte J. et al. Human chorionic gonadotropin as a central regulator of pregnancy immune tolerance. J Immunol. 2013, 190, 2650-2658.
- Schumacher A., Brachwitz N., Sohr S. et al. Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy. J. Immunol. 2009, 182, 5488-5497.
- Заморина С. А., Ширшев С. А. Хорионический гонадотропин - фактор индукции иммунной толерантности при беременности. Иммунология 2013, 34(2), 105-107.
- Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2004, 299, 1057-1061.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).