IMMUNOGENETIC ASPECTS OF THE FORMATION OF CONGENITAL CONOTRUNCUS WITHOUT CHROMOSOMAL DISEASES

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Abstract

The study showed the role of the gene HLA-G 3’UTR in the development of congenital malformations of conotruncus. The study included 14 children with tetralogy of Fallot and 103 healthy children. HLAG 3’UTR typing was performed by amplification of polymorphic gene sites by allele-specific polymerase chain reaction (PCR), in accordance with the manufacturer’s Protocol (Applied Biosystems, USA), with further detection of results in polyacrylamide gel. The study found that in the group of children with a tetralogy of Fallot homozygous genotype HLA-G 3’UTR14-bp ins/ins met statistically significantly more often than in the control group.

About the authors

N. S. Deeva

Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases»;
Federal state budgetary educational institution of higher education «Kemerovo state medical University» of the Ministry of health of the Russian Federation

Author for correspondence.
Email: fake@neicon.ru

laboratory assistant-researcher of the laboratory of cellular technologies,

Kemerovo

Russian Federation

A. V. Tsepokina

Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases»

Email: fake@neicon.ru

junior researcher of the laboratory of genomic medicine,

Kemerovo

Russian Federation

A. V. Shabaldin

Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases»;
Federal state budgetary educational institution of higher education «Kemerovo state medical University» of the Ministry of health of the Russian Federation

Email: weit2007@yandex.ru

M.D., leading researcher of laboratory of cell technologies,

Kemerovo

Russian Federation

S. A. Shmulevich

State budgetary institution of health care «Kemerovo regional clinical cardiology clinic named after academician L. S. Barbarash»

Email: fake@neicon.ru

PhD, head of children’s Department,

Kemerovo

Russian Federation

E. N. Voronina

Federal state budgetary scientific institution «Institute of chemical biology and fundamental medicine of the Siberian branch of the Russian Academy of Sciences»

Email: fake@neicon.ru

PhD, researcher of the laboratory of pharmacogenomics,

Kemerovo

Russian Federation

M. L. Filipenko

Federal state budgetary scientific institution «Institute of chemical biology and fundamental medicine of the Siberian branch of the Russian Academy of Sciences»

Email: fake@neicon.ru

PhD, head of the laboratory of pharmacogenomics,

Kemerovo

Russian Federation

E. V. Shabaldina

Federal state budgetary educational institution of higher education «Kemerovo state medical University» of the Ministry of health of the Russian Federation

Email: fake@neicon.ru

M.D., head of the Department of otolaryngology,

Kemerovo

Russian Federation

References

  1. Hinton R. B. Genetic and environmental factors contributing to cardiovascular malformation: a unified approach to risk. J Am Heart Assoc 2014;3: e000292.
  2. Yu D., Feng Y., Yang L., Da M., Fan C., Wang S., Mo X. Maternal Socioeconomic Status and the Risk of Congenital Heart Defects in Off spring: A Meta-Analysis of 33 Studies. Wallace GR, ed. PLoS ONE. 2014.
  3. Mandò Ch., Pileri P., Mazzocco M. I., Lattuada D., Zolin A., Plebani M. Maternal and fetal HLA-G 14 bp gene polymorphism in pregnancy-induced hypertension, preeclampsia, intrauterine growth restricted and normal pregnancies. The Journal of Maternal-Fetal & Neonatal Medicine, 2016, V.29(9); 1509–15.

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Copyright (c) 2019 Deeva N.S., Tsepokina A.V., Shabaldin A.V., Shmulevich S.A., Voronina E.N., Filipenko M.L., Shabaldina E.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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