Email this article Peculiarities of the exposure of the antibiotics of the macrolid group on the functional activity of neutrophilic granulocytes of peripheral blood in vitro
- Authors: Baturina I..1, Savochkina A..1, Gromakova K..1,2, Nikushkina K..1, Emelyanov I..1,2, Zotova M..1, Mezentseva E..1
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Affiliations:
- South Ural State Medical University
- Chelyabinsk State University
- Issue: Vol 21, No 3 (2018)
- Pages: 216-221
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/868
- DOI: https://doi.org/10.31857/S102872210002384-7
- ID: 868
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Abstract
Dose-dependent eff ects of antibiotics and their eff ect on immune cells of the body, in particular neu-trophilic granulocytes, are still poorly understood. The method of fl ow cytometry was determined by the minimum eff ective dose of chemomycin by assessing the degranulation of neutrophils. It was found that under the action of minimum eff ective dose chemomycin neutrophils form neutrophil extracellular traps (NETs), which are one of the mechanisms of adaptive immunity. It is noteworthy that the release of NETs in response to the action of chemomycin was not dependent on gender.
About the authors
I. . Baturina
South Ural State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. . Savochkina
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
K. . Gromakova
South Ural State Medical University; Chelyabinsk State University
Email: noemail@neicon.ru
Russian Federation
K. . Nikushkina
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
I. . Emelyanov
South Ural State Medical University; Chelyabinsk State University
Email: noemail@neicon.ru
Russian Federation
M. . Zotova
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
E. . Mezentseva
South Ural State Medical University
Email: noemail@neicon.ru
Russian Federation
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).