IgAs, IL-4, and BAFF in nasal fluid and CD20+ B cells in nasopharyngeal tonsil in transient hypogammaglobulinaemia of infancy
- Authors: Климов V..1, Klimov A..1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 21, No 3 (2018)
- Pages: 321-324
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/887
- DOI: https://doi.org/10.31857/S102872210002403-8
- ID: 887
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Abstract
24 children at the age from 6 months to 4 years with recurrent respiratory infections and 12 children at the same age with transient hypogammaglobulinaemia of infancy (THI) were examined. An essential decrease in IgAs and BAFF in nasal fl uid and the CD20+ expression on nasopharyngeal tonsil’s B cells in children with THI has registered.
About the authors
V. . Климов
Siberian State Medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
A. . Klimov
Siberian State Medical University
Email: noemail@neicon.ru
Russian Federation
References
- Oliveira J.B., Fleisher T. A. Laboratory evaluation of primary immunodefi ciencies. J Allergy Clin Immunol 2010, 125 (2), 297–305.
- Ovadia A., Dalal I. Transient hypogammaglobulinemia of infancy. LymphoSign Journal 2014, 1 (1), 1–9.
- Whelan M. A., Hwan W. H., Beausoleil J. et al. Infants presenting with recurrent infections and low immunoglobulins: characteristics and analysis of normalization. J. Clin. Immunol 2006, 26, 7–11.
- Bukowska-Strakova К., Kowalczyk D., Baran J. et al. The B-cell compartment in the peripheral blood of children with diff erent types of primary immunodefi - ciency. Pediatr Res 2009, 66, 28–34.
- Artac H., Kara R., Gokturk B., Reisli I. Reduced CD19 expression and decreased memory B cell numbers in transient hypogammaglobulinemia of infancy. Clin Exp Med 2013, 13(4), 257–263.
- Huck K., Feyen O., Ghosh S., Beltz K., Bellert S., Niehues T. Memory B-cells in healthy and antibody-defi - cient children. Clin. Immunol 2009, 131 (1), 50–59.
- Климов А. В., Деев И. А., Климов В. В. Содержание IgAs, IL-10 и BAFF в назальных секретах у детей с транзиторной гипогаммаглобулинемией детского возраста. Российский иммунологический журнал 2016, 10 (19) (3), 279–280. [Klimov A. V., Deev I. A., Klimov V. V. IgAs, IL-10 and BAFF in nasal fl iud in transient hypogammaglobulinemia of infancy. Russian Journal of Immunology 2016, (19) (3), 279–280].
- Henley T. B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta. Eur J Immunol 2008, 38 (12), 3543–3548.
- Cipe F. E., Dogu F, Guloglu D. et al. B-cell subsets in patients with transient hypogammaglobulinemia of infancy, parcial IgA defi ciency, and selective IgM defi ciency. J Investig Allergol Clin Immunol 2013, 23 (2), 94–100.