Email this article Peripheral blood cytotoxic T cells in patients with sarcoidosis
- Authors: Lazareva N..1,2, Kudryavtsev I..1,3, Baranova O..1, Serebriakova M..3, Ses’ T..1,2, Ilkovich M..1, Totolyan A..1,4
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Affiliations:
- Academician I.P. Pavlov First St. Petersburg State Medical University
- State Research Institute of Highly Pure Biopreparations
- Institute of Experimental Medicine
- St. Petersburg Pasteur Institute
- Issue: Vol 21, No 3 (2018)
- Pages: 348-353
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/892
- DOI: https://doi.org/10.31857/S102872210002408-3
- ID: 892
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Abstract
Based on CD45RA, CD62L, CD27 и CD28 expression several subsets of peripheral blood CD3+CD8+ lymphocytes were measured in patients with chronic sarcoidosis (n=46). The percentage of “non-eff ector” CD3+CD8+ subsets – “naïve” and central memory – were decreased in comparison with healthy control group (n=46), whereas the relative number of TEMRA cells was signifi cantly increased. Within EM subset percentage of EM1 cells was lower in sarcoidosis group, while among TEMRA the relative number of рЕ2 and mature eff ector cells were increased if compared with healthy control group. Thereby, our results indicate the intensifi cation of CD3+CD8+ lymphocytes maturation in the lymphoid tissue under a constant antigenic stimulation.
About the authors
N. . Lazareva
Academician I.P. Pavlov First St. Petersburg State Medical University; State Research Institute of Highly Pure Biopreparations
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
I. . Kudryavtsev
Academician I.P. Pavlov First St. Petersburg State Medical University; Institute of Experimental Medicine
Email: noemail@neicon.ru
Russian Federation
O. . Baranova
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: noemail@neicon.ru
Russian Federation
M. . Serebriakova
Institute of Experimental Medicine
Email: noemail@neicon.ru
Russian Federation
T. . Ses’
Academician I.P. Pavlov First St. Petersburg State Medical University; State Research Institute of Highly Pure Biopreparations
Email: noemail@neicon.ru
Russian Federation
M. . Ilkovich
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: noemail@neicon.ru
Russian Federation
A. . Totolyan
Academician I.P. Pavlov First St. Petersburg State Medical University; St. Petersburg Pasteur Institute
Email: noemail@neicon.ru
Russian Federation
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).