Spontaneous and stimulated CD25 expression on T-lymphocytes and the amount of regulatory T-cells in children with chronic hepatitis C

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Abstract

Children of 6–17 years old with viral chronic hepatitis C (n=24) and conditionally healthy controls of corresponding age (n=32) were examined. The amount of CD3+CD25+, CD4+CD25+ и CD8+CD25+ and regulatory T-cells (Treg, CD3+CD4+CD25+CD127low/neg) were investigated by fl ow cytometry. In children with chronic hepatitis C the number of phytohemagglutinin-stimulated CD3+CD25+, CD4+CD25+ and Treg was decreased, the amount of CD8+CD25+ in conditions of stimulation by antibodies to CD3 and combined stimulation by antibodies to CD3 and CD28 was too decreased.

About the authors

I. . Pashnina

Regional Children’s Clinical Hospital № 1; Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

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