Subpopulation structure of T-lymphocytes in children with diff erent activity of juvenile idiopathic arthritis

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Abstract

Children of 6–17 years old with diff erent activity of juvenile idiopathic arthritis were examined: 74 with active arthritis and 14 with remission were treated with disease modifying therapy, 12 children with persistent remission and 32 apparently healthy children were without medications. The amount of CD3+, CD3+CD4+, CD3+CD8+, СD3+СD4–СD8–, СD3+СD4+СD8+, СD3+СD16/56+, СD3+СD4+СD25+СD127low/neg and СD3+СD4+СD25+СD127+ were investigated by fl ow cytometry. In all children with juvenile idiopathic arthritis the number regulatory T-cells (CD3+CD4+CD25+CD127low/neg) and double-positive lymphocytes (СD3+СD4+СD8+) was decreased. The amount of NKT (СD3+СD16/56+) in patients with active arthritis and with remission was too decreased.

About the authors

I. . Pashnina

Regional Children’s Clinical Hospital № 1; Institute of Immunology and Physiology, Urals Branch of the Russian Acad. Sci.

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

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