Email this article Dynamics of the functional status of neutrophilic granulocytes of urogenital secrets and neutrophiles allocated from the peripheral blood of women in various phase of the menstrual cycle
- Authors: Samuseva I..1
-
Affiliations:
- South Ural state medical University
- Issue: Vol 21, No 3 (2018)
- Pages: 423-427
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/905
- DOI: https://doi.org/10.31857/S102872210002421-8
- ID: 905
Cite item
Full Text
Abstract
The paper presents the results of analysis of the dynamics of the phagocytic reaction of neutrophils and the formation of extracellular DNA networks in the secrets of the urogenital tract and in the isolated pure fraction of neutrophilic granulocytes in the presence of cellular activators, depending on the phase of the menstrual cycle. It was found that the functional status of neutrophils in conditionally healthy women in the second half of the menstrual cycle is higher in comparison with the fi rst. This is probably due to increased reactivity of neutrophils with a more pronounced female hormonal profi le, which is observed in the second phase of the menstrual cycle and during pregnancy, which apparently plays an important role in protecting the urogenital tract of the pregnant woman and fetus.
About the authors
I. . Samuseva
South Ural state medical University
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
References
- Семенов Б.Ф., Зверев В. В. Концепция создания быстрой иммунологической защиты от патогенов. Журнал микробиологии, эпидемиологии и иммунобиологии 2007; 4: 93–100. [Semenov B. F., Zverev V. V. The concept of creating a rapid immunological defense against pathogens. Journal of Microbiology, Epidemiology and Immunobiology 2007; 4: 93–100].
- Herant E. Mechanisms of neutrophil phagocytosis. Journal of cell science 2003;19: 45–50.
- Скулачев В. П. Кислород в живой клетке: добро и зло, Соросовский образовательный журнал 1996; 2: 23–27 [Skulachev V. P. Oxygen in a living cell: good and evil, Soros Educational Journal 1996; 2: 23–27].
- Halliwell B., Gutteridge J., Modulating A. Role for Antioxidants in Desiccation Tolerance/ Halliwell B. Biology 1998; l (45): 734–740.
- Гольдштейн Н. И. Активные формы кислорода как жизненно необходимые компоненты воздушной среды. Биохимия 2002; 67: 194–204. [Goldstein N. I. Active forms of oxygen as vital components of the air environment. Biochemistry 2002; 67: 194–204].
- Delanty N., Dichter M. Oxidative injury in the nervous system. Acta Neurologica Scandinavica1998; 9: 145–153.
- Савочкина А. Ю. Нейтрофильные внеклеточные ловушки: механизмы образования, методы обнаружения, биологическая роль: диссертация доктора медицинских наук. Челябинская государственная медицинская академия. – Челябинск, 2012. – 212c. [Savochkina A. Yu. Neutrophilic extracellular traps: mechanisms of formation, methods of detection, biological role. dis. MD, PhD, Chelyabinsk state medical Academy. – Chelyabinsk, 2012. –212 p.]
- Brinkmann V., Zychlinsky V. Why neutrophils die to, make NETs. Nature 2007; 5: 577–582.
- Смирнова Т. Г. Влияние женских половых стероидных гормонов на механизм внутри – и внеклеточной бактерицидности фагоцитирующих клеток: диссертация кандидата биологических наук. Челябинская государственная медицинская академия. – Челябинск, 2014. –201c. [Smirnova T. G. The infl uence of female sex steroid hormones on the mechanisms of intra – and extracellular bacteriacidal activity of phagocytic cells: thesis PhD, Chelyabinsk state medical Academy.– Chelyabinsk, 2014.– 201p.].
- Турпаев К. Т. Активные формы кислорода и регуляция экспрессии генов. Биохимия 2002;3: 281–292. [Turpaev K. T. Active forms of oxygen and regulation of gene expression. Biochemistry 2002;3:281–292].
- Mc.Cord J. M. Prevention of Neutrophil-Mediated Hepatic Ischemia. Reperfusion Injury by Superoxide Dismutase and Catalase Derivatives. The journal of pharmacology 1995; 34 (1): 231–243.
- Oberley T. D., Toyokuni S., Szweda L. Localization of hydroxynonenal protein adducts in normal human kidney and selected human kidney cancers. Free Radic Biol Med 1999; 27(5–6): 695–703.
- Beyrau M., Bodkin J. V, Nourshargh S. Neutrophil heterogen ity in health and disease: a revitalized avenue in infl ammation and immunity. Open Biol 2012; 2(11): 120–134.
- Маркова В. А. Сравнительный анализ функциональных свойств нейтрофильных гранулоцитов периферической крови и мукозальных секретов у здоровых мужчин и женщин: диссертация кандидата биологических наук. Челябинская государственная медицинская академия. – Челябинск, 2014. –136 c. [Markova V. A. Comparative analysis of functional properties of neutrophilic granulocytes of peripheral blood and mucosal secretions in healthy men and women: thesis PhD, Chelyabinsk state medical Academy. – Chelyabinsk, 2014. –136 p.].
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).