Email this article The role of TCR-activation in the formation of small subpopulations of T helpers
- Authors: Timganova V.1, Zamorina S.1, Bochkova M.1, Khramtsov P.1, Raev M..1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Issue: Vol 21, No 3 (2018)
- Pages: 449-453
- Section: ORIGINAL ARTICLES
- Submitted: 22.10.2020
- Published: 15.07.2018
- URL: https://rusimmun.ru/jour/article/view/910
- DOI: https://doi.org/10.31857/S102872210002426-3
- ID: 910
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Abstract
The role of the independent eff ect of TCR-activation in the formation of small subpopulations of T-helpers (Treg, TCM, TEM, TEMRA) was studied. It was shown that under the conditions of TCR activation, cells were redistributed in favor of eff ector subpopulations (TEM, TEMRA), while the number of naive T cells and TCM decreased. What about Treg, it was demonstrated that TCR-activation of cells resulted in increased intracellular expression of FOXP3, HELIOS and CTLA-4. In general, the presence of the TCR-activator leads to an increase in the number of eff ector T-helpers, which is accompanied by a simultaneous increase in the level of suppressive Treg.
About the authors
Valeriya Timganova
Institute of Ecology and Genetics of Microorganisms UB RAS
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
Svetlana Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
Russian Federation
Maria Bochkova
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
Russian Federation
Pavel Khramtsov
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
Russian Federation
M. . Raev
Institute of Ecology and Genetics of Microorganisms UB RAS
Email: noemail@neicon.ru
Russian Federation
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