Email this article CORRELATION OF VITAMIN D, FOOD HYPERSENSITIVITY AND PROINFLAMMATORY CYTOKINES IN CHILDREN WITH AUTISM SPECTRUM DISORDERS
- Authors: Khudiakova M.I.1, Cherevko N.A.1, Berezovskaya K.V.2
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Affiliations:
- Siberian State Medical University
- Center of Family Medicine
- Issue: Vol 22, No 4 (2019)
- Pages: 1543-1545
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/968
- DOI: https://doi.org/10.31857/S102872210007084-7
- ID: 968
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Abstract
The study investigated the relationship between the concentration of 25-OH vitamin D, food hypersensitivity and the level of pro-inflammatory cytokines in children with ASD. An inversecorrelation was found between the concentration of vitamin D and specific IgG (sIgG) to food antigens of dairy and grain products, concentration of pro-inflammatory cytokines (IL17, IFNγ). Thus, deficiency of vitamin D is associated with indicators of immune inflammation and the mechanisms of food tolerance in children with ASD.
Keywords
About the authors
M. I. Khudiakova
Siberian State Medical University
Author for correspondence.
Email: khudiakovami@mail.ru
PhD applicant,
Tomsk
Russian FederationN. A. Cherevko
Siberian State Medical University
Email: fake@neicon.ru
Grand PhD in Medical sciences, Professor of the Department of Allergology and Immunology,
Tomsk
Russian FederationK. V. Berezovskaya
Center of Family Medicine
Email: fake@neicon.ru
general practitioner, pediatrician,
Tomsk
Russian FederationReferences
- Siniscalco D., Schultz S., Brigida A., Antonucci N. Infl ammation and neuro-immune dysregulations in autism spectrum disorders. Pharmaceuticals. 2018, 11(2), 56.
- Christensen D.L., Baio J., Braun K. V. N., Bilder D., Charles J., Constantino J. N. Prevalence and characteristics of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network. MMWR Surveillance Summaries.2016, 65(3), 1–23.
- De Magistris L., Picardi A., Siniscalco D., Riccio M.P., Sapone A., Cariello R., Abbadessa S., Medici N., Lammers K.M., Schiraldi C., Iardino P. Marotta R., Tolone C., Fasano A., Pascotto A., Bravaccio C. Antibodies against food antigens in patients with autistic spectrum disorders. BioMedresearchinternational. 2013.
- Черевко Н. А., Скирневская А. В., Розенштейн М. Ю., Новиков П. С., Муравейник О. А., Денисов А. А. Особенности специфической гиперчувствительности к пищевым антигенам молочного и злакового кластеров у детей с расстройством аутистического спектра. Бюллетень сибирской медицины. 2018, 17(1), 159–166.
- Cannell J. J., Grant W. B. What is the role of vitamin D in autism? Dermato-endocrinology. 2013, 5(1), 199–204.
- Розенштейн М. Ю., Розенштейн А. З., Кондаков С. Э., Черевко Н. А. Современные лабораторные методы диагностики пищевой непереносимости. Бюллетень сибирской медицины. 2016; 15 (1): 69–78.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).