Email this article Immune reactions to clinical carcinogens and steroid hormones in breast pre-cancer and cancer patients
- Authors: Glushkov A.N.1, Polenok E.G.1,2, Gordeeva L.A.1, Mun S.A.1, Kostyanko M.V.3, Kolpinckiy G.I.2,4, Vafin I.A.5, Antonov A.V.6, Verzhbitskaja N.E.6
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Affiliations:
- Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry
- Kemerovo State Medical University
- Kemerovo State University
- Kemerovo Clinical Diagnostic Сenter
- Kuzbass Center of Blood
- Kuzbass Clinical Oncology Dispensary
- Issue: Vol 24, No 1 (2021)
- Pages: 101-108
- Section: ORIGINAL ARTICLES
- Submitted: 04.12.2020
- Published: 15.01.2021
- URL: https://rusimmun.ru/jour/article/view/977
- DOI: https://doi.org/10.46235/1028-7221-977-IRT
- ID: 977
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Abstract
Detection of postmenopausal women at high risk for breast pre-cancer and cancer is a key condition to prevent these diseases. Aim of our research was to study possible usage of immunoassay for antibodies specific to benzo[a]pyrene, estradiol, and progesterone (IgA-Bp, IgA-Es, IgA-Pg) in determination of personal risks for fibrocystic disease and breast cancer at the early stage, with respect to hormone receptor status in tumor tissues. Blood serum IgA-Bp, IgA-Es, IgA-Pg were studied by ELISA in postmenopausal women: healthy controls (n = 401), patients with fibrocystic breast disease (n = 50), and breast cancer (stage I, n = 575, stages II-IV, n = 861). High individual IgA-Bp/IgA-Pg ratios of > 1.5 were found in 19.7% of healthy women, and in 50.0% of fibrocystic breast disease patients (p < 0.0001; OR = 4.1). IgA-Es/IgA-Pg ratios of > 1.0 were revealed in 48.4% healthy women and in 68.0% fibrocystic breast disease patients (p < 0.01; OR = 2.3). IgA-Bp/IgAPg values > 1.0 were found in 41.9% of healthy women, and, at higher rates, in the patients with breast cancer stage I: 68.3% ER- tumors (p < 0.0001; OR = 3.0) and 75.9% ER+ tumors (p < 0.0001; OR = 4.4). IgA-Es/ IgA-Pg ratios > 1.0 were revealed in 48.4% of healthy women, and in patients with breast cancer stage I: 65.3% ER- tumors (p < 0.003; OR = 2.0), and 76.8% ER+ tumors (p < 0.0001; OR = 3.5). Some associations of studied antibodies with cancer progression were revealed. Frequency of individual cases with IgA-Bp/IgA-Pg > 1.0 in patients with ER- tumors increased from 12.0% at stage I to 19.9% at stage II. Frequency of cases with IgA-Bp/IgA-Pg > 1.0 in the patients with ER+ tumors decreased from 62.0% at stage I to 57.3% at stage II (p = 0.002). Frequency of cases with IgA-Es/IgA-Pg > 1.0 in the patients with ER- tumors increased from 11.5% at stage I to 21.4% at stage II. Frequency of cases with IgA-Es/IgA-Pg > 1.0 in patients with ER+ tumors decreased from 63.3% at stage I to 56.1% at stage II (p < 0.001). The cases with individual excessive IgA-Bp and IgA-Es levels are associated with fibrocystic breast disease and ER+ breast cancer at the onset of the disease. Breast cancer progression was associated with the relative decrease of ER in tumor tissues, along with higher individual levels of IgA-Bp and IgА-Es and lower IgA-Pg levels. ELISA testing of IgА-Bp, IgА-Es, IgA-Pg could be recommended for detection of individual risk for fibrocystic breast disease and stage I of breast cancer, as well as for more efficient prevention and therapy by selective modulators of estrogen receptor (raloxifene, arzoxifene and lasofoxifine) and aromatase inhibitors (exemestane, anastrozole).
About the authors
A. N. Glushkov
Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry
Email: glushkovan@ihe.sbras.ru
ORCID iD: 0000-0002-8560-6719
Glushkov Andrew N., PhD, MD (Medicine), Professor, Chief Research Associate, Laboratory of Immunogenetics, Institute of Human Ecology
Kemerovo
SPIN-код (РИНЦ) 9536-8530;
AuthorID (Scopus) 7006323832;
ResearcherID (WOS) Q-5985-2016
Russian FederationE. G. Polenok
Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry;Kemerovo State Medical University
Email: egpolenok@mail.ru
ORCID iD: 0000-0002-9368-2340
Polenok Elena G., PhD (Pharmacy), Leading Research Associate, Laboratory of Immunochemistry, Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry; Associate Professor, Department of Biology with the Basics of Genetics and Parasitology, Kemerovo State Medical University
Kemerovo
SPIN-код (РИНЦ) 3925-0185;
AuthorID (Scopus) 6506567994;
ResearcherID (WOS) Q-5381-2016
Russian FederationL. A. Gordeeva
Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry
Email: gorsib@rambler.ru
ORCID iD: 0000-0001-5870-7584
Gordeeva Ludmila A., PhD (Biology), Leading Research Associate, Laboratory of Immunogenetics, Institute of Human Ecology
Kemerovo
SPIN-код (РИНЦ) 6662-4616;
AuthorID (Scopus) 14052058500;
ResearcherID (WOS) R-2781-2016
Russian FederationS. A. Mun
Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry
Author for correspondence.
Email: stellamun@yandex.ru
ORCID iD: 0000-0002-5530-3469
Mun Stella A., PhD (Medicine), Senior Research Associate, Laboratory of Immunogenetics, Institute of Human Ecology
650065, Kemerovo, Leningradsky ave, 10
SPIN-код (РИНЦ) 5579-8939;
AuthorID (Scopus) 7101645456;
ResearcherID (WOS) J-6484-2018
Russian FederationM. V. Kostyanko
Kemerovo State University
Email: kmvksu@mail.ru
Kostyanko Mikhail V., Leading Engineer, Department of Organic Chemistry
Kemerovo
SPIN-код (РИНЦ) 5953-6554;
Author ID (Scopus) 6507008191
Russian Federation
G. I. Kolpinckiy
Kemerovo State Medical University;Kemerovo Clinical Diagnostic Сenter
Email: Glebss@mail.ru
Kolpinsky Gleb I., PhD, MD (Medicine), Professor, Department of Radiology, Radiotherapy and Oncology, Kemerovo State Medical University; Main Physician, Kemerovo Clinical Diagnostic Сenter
Kemerovo
SPIN-код (РИНЦ) 6894-6419,
AuthorID (Scopus) 56677706300
Russian FederationI. A. Vafin
Kuzbass Center of Blood
Email: gkuz.kots@yandex.ru
Chief Physician
Kemerovo
Russian FederationA. V. Antonov
Kuzbass Clinical Oncology Dispensary
Email: al0412@mail.ru
Antonov Alexander V., Head, Oncological Department No. 5
Kemerovo
Russian FederationN. E. Verzhbitskaja
Kuzbass Clinical Oncology Dispensary
Email: verzhbitskaja@mail.ru
Verzhbitskaya Natalia E., PhD (Medicine), Chief, Department of Pathology
Kemerovo
Russian FederationReferences
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