THYMUS IN AUTOIMMUNE DISEASES CLINIC. THE ACTUALITY AND PROSPECTIVES OF “IN VIVO” MONITORING

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Abstract

The leading role of Thymus in adoptive immunity development was established 50 years ago. Nevertheless T-cells immunity monitoring in clinical immunology is now testing of growing number of “immune periphery” items disregarding thymus as a central T-immunity organ. We showed that T-cells rearrangement excision circles (TREC) could be the important chain in thymus and peripheral T-cells function assessment in adult and aged healthy donors and rheumatoid arthritis patients. It will create the possibility to form more complex “in vivo” monitoring of thymus activity in autoimmunity.

About the authors

M. V. Goloviznin

A.I Evdokimov Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: ordinatormgmsu@mail.ru

PhD, Associate professor of the Department of Internal Diseases of dental faculty,

Moscow

Russian Federation

N. S. Lakhonina

A.I Evdokimov Moscow State University of Medicine and Dentistry

Email: fake@neicon.ru

Assistant professor of the Department of Internal Diseases of dental faculty,

Moscow

Russian Federation

V. T. Timofeev

N.I.Pirogov Russian Scientifi c-Research State Medical University

Email: fake@neicon.ru

D. Sci, Leading researcher of Faculty therapy department,

Moscow

Russian Federation

Yu. R. Buldakova

A.I Evdokimov Moscow State University of Medicine and Dentistry

Email: fake@neicon.ru

PhD, Associate professor of the Department of Internal Diseases of dental faculty,

Moscow

Russian Federation

References

  1. Хайдуков С. В. Малые субпопуляции Т-хелперов (Th наивные тимические, Th наивные центральные, Th9, Th22 и CD4+CD8+ дважды положительные Т-клетки) // Медицинская иммунология. – 2013. – том 15, № 6 – С. 503–512.
  2. Донецкова А. Д., Ярилин А. А. T-рецепторные эксцизионные кольца и значимость их определения в клинике // Иммунология. – 2013. – № 4. – С. 220– 226.
  3. Ярилин А. А. Основы иммунологии. – Москва: «Медицина», 1999 г. – 608 с.

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Copyright (c) 2019 Goloviznin M.V., Lakhonina N.S., Timofeev V.T., Buldakova Y.R.

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