COMPARATIVE ANALYSIS OF THE INDICATORS OF THE FUNCTIONAL ACTIVITY OF NEUTROPHILS PERIPHERAL BLOOD IN PATIENTS WITH SEVERE SEPSIS AND SEPTIC SHOCK

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Authors: Dolgushin I.I.¹, Savochkina A.Y.¹, Pykhova L.R.¹, Abramovskihk O.S.¹, Chetvernina E.A.¹, Poltorak A.E.²
Affiliations:
1. South Ural State Medical University
2. Chelyabinsk Regional Clinical Hospital
Issue: Vol 22, No 2-1 (2019)
Pages: 236-238
Section: ORIGINAL ARTICLES
Submitted: 16.04.2020
Accepted: 16.04.2020
Published: 15.04.2019
URL: https://rusimmun.ru/jour/article/view/100
DOI: https://doi.org/10.31857/S102872210006587-0
ID: 100

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Abstract

A comparative analysis of the functional activity of peripheral blood neutrophils in patients with sepsis, depending on the severity of the disease, has been carried out. An increase in the total number of leukocytes, neutrophil extracellular networks, indicators of neutrophil absorption activity and the activity of intracellular oxygen-dependent metabolism of neutrophils in patients with septic shock was detected.

Keywords

severe sepsis, septic shock, neutrophil extracellular traps

About the authors

I. I. Dolgushin

South Ural State Medical University

Author for correspondence.
Email: fake@neicon.ru

Ph.D. Professor of the department of Microbiology, Virology, Immunology and CLD, academician of RAS, honored scientist of the RF, president,

Chelyabinsk

Russian Federation

A. Y. Savochkina

South Ural State Medical University

Email: alina7423@mail.ru

Ph.D. Professor of the department of Microbiology, Virology, Immunology and CLD,

Chelyabinsk

Russian Federation

L. R. Pykhova

South Ural State Medical University

Email: fake@neicon.ru

Senior laboratory assistant of the central research laboratory,

Chelyabinsk

Russian Federation

O. S. Abramovskihk

South Ural State Medical University

Email: fake@neicon.ru

Ph.D. Professor of the department of Microbiology, Virology, Immunology and CLD,

Chelyabinsk

Russian Federation

E. A. Chetvernina

South Ural State Medical University

Email: fake@neicon.ru

Assistant of the department of Microbiology, Virology, Immunology and CLD,

Chelyabinsk

Russian Federation

A. E. Poltorak

Chelyabinsk Regional Clinical Hospital

Email: fake@neicon.ru

doctor surgeon of surgical department № 1,

Chelyabinsk

Russian Federation

References

Shankar-Hari M., Phillips G. S., Levy M. L., Seymour C. W., Liu V. X., Deutschman C. S., Angus D. C., Rubenfeld G. D., Singer M. Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). J.A.M.A. 2016, 315(8), 775–787.
Долгушин И. И., Торопова Л. Р., Савочкина А. Ю., Абрамовских О. С., Четвернина Е. А., Полторак А. Е. Динамика изменения показателей функциональной активности нейтрофилов у больных сепсисом с неблагоприятным исходом. Российский иммунологический журнал 2017, 11(20), 2, 295–296.
Brinkmann V., Rechard V., Goosmann C., Fauler B., Uhlemann Y., Weiss D. S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science 2004, 303, 1532–1535.
Савочкина А. Ю., Пыхова Л. Р., Абрамовских О. С., Полторак А. Е., Четвернина Е. А. Сравнительный анализ показателей функциональной активности нейтрофилов периферической крови у больных с сепсисом в зависимости от исхода. Российский иммунологический журнал 2018, 12(21), 4, 407–411

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Copyright (c) 2019 Dolgushin I.I., Savochkina A.Y., Pykhova L.R., Abramovskihk O.S., Chetvernina E.A., Poltorak A.E.

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