Email this article POLYMORPHISM OF ENZYMES OF BIOTRANSFORMATION OF XENOBIOTICS (GLUTATHIONE S-TRANSFERASES M1, T1, P1) IN PATIENTS WITH A COMBINATION OF ATOPIC DERMATITIS AND BRONCHIAL ASTHMA
- Authors: Molokova A.V.1
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Affiliations:
- Novosibirsk state medical University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 417-419
- Section: ORIGINAL ARTICLES
- Submitted: 06.05.2020
- Accepted: 06.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/169
- DOI: https://doi.org/10.31857/S102872210006916-2
- ID: 169
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Abstract
The study of polymorphism of glutathione S-transferases M1, T1, P1 in children with allergic diseases showed a predominance of mutant enzyme genotypes in severe atopic dermatitis and asthma. Genotypes GSTM1«-», GSTT1«-» are signifi cant for the early formation of atopic dermatitis and bronchial asthma. Predisposition to combined atopy was registered for haplotypes M1«+»/T1«-»/P1ile105/Ile105 (OR=4.92; 95% CI 0.67–36.53) (р<0,05).
About the authors
A. V. Molokova
Novosibirsk state medical University
Author for correspondence.
Email: fake@neicon.ru
PhD, Department of Pediatrics,
Novosibirsk
Russian FederationReferences
- Warholm M., Rane A., Alexandrie A. K. Genotypic and phenotypic determination of polymotphic glutathione transferase T1 in a Swedish population. Pharmacogenetics. 1995; 5, 252–254.
- Zhong S., Wyllie A. H., Barnes D. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis. 1993; 14, 1821–1824.
- Pemble S., Schroeder K. R., Spencer S. R. Human glutathione S-transferase Theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem. J. 1994; 300, Pt. 1, 271–276.
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